Biosynthesis and metabolism of endothelium-derived nitric oxide

LJ Ignarro - Annual review of pharmacology and toxicology, 1990 - annualreviews.org
… It may be of interest that, unlike its spontaneously generated product NO, S-nitrosocysteine
itself is not paramagnetic (KS Wood, LJ Ignarro, unpublished observations). As discussed …

Endothelium‐derived nitric oxide: actions and properties

LJ Ignarro - The FASEB Journal, 1989 - Wiley Online Library
Vascular smooth muscle relaxation in response to chemically diverse naturally occurring
neurotransmitters and autacoids has been attributed to the formation and/or release of one or …

Biological actions and properties of endothelium-derived nitric oxide formed and released from artery and vein.

LJ Ignarro - Circulation research, 1989 - Am Heart Assoc
… Gruetter CA, Kadowitz PJ, Ignarro LJ: Methylene blue inhibits coronary arterial relaxation
and guanylate cyclase activation by nitrogjycerin, sodium nitrite and amyl nitrite. CanJPhysiol …

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

LJ Ignarro, GM Buga, KS Wood… - Proceedings of the …, 1987 - National Acad Sciences
The objective of this study was to determine whether nitric oxide (NO) is responsible for the
vascular smooth muscle relaxation elicited by endothelium-derived relaxing factor (EDRF). …

[BOOK][B] Nitric oxide: biology and pathobiology

LJ Ignarro - 2000 - books.google.com
Nitric oxide (NO) is a gas that transmits signals in an organism. Signal transmission by a gas
that is produced by one cell and which penetrates through membranes and regulates the …

[PDF][PDF] Mechanism of vascular smooth muscle relaxation by organic nitrates, nitrites, nitroprusside and nitric oxide: evidence for the involvement of S-nitrosothiols as …

LJ Ignarro, H Lippton, JC Edwards, WH Baricos… - … of Pharmacology and …, 1981 - Citeseer
The objective of this study was to ascertain whether the vasodilator effect of organic nitrates
and nitrites, NaNO2, nitroprusside and NO could be attributed to the formation and action of …

Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.

LJ Ignarro, RE Byrns, GM Buga, KS Wood - Circulation research, 1987 - Am Heart Assoc
The objective of this study was to elucidate the close similarity in properties between
endothelium-derived relaxing factor (EDRF) and nitric oxide radical (NO). Whenever possible, a …

[HTML][HTML] Nitric oxide as a mediator of relaxation of the corpus cavernosum in response to nonadrenergic, noncholinergic neurotransmission

…, PA Bush, FJ Dorey, LJ Ignarro - New England Journal …, 1992 - Mass Medical Soc
Background. Nitric oxide has been identified as an endothelium-derived relaxing factor in
blood vessels. We tried to determine whether it is involved in the relaxation of the corpus …

Microglial cell cytotoxicity of oligodendrocytes is mediated through nitric oxide.

JE Merrill, LJ Ignarro, MP Sherman… - … (Baltimore, Md.: 1950 …, 1993 - journals.aai.org
Rat ameboid microglia are able to lyse rat oligodendrocytes in vitro. The lysis is inhibited by
transforming growth factor-beta, antagonists of nitric oxide (NO) production, as well as …

Oxidation of nitric oxide in aqueous solution to nitrite but not nitrate: comparison with enzymatically formed nitric oxide from L-arginine.

LJ Ignarro, JM Fukuto, JM Griscavage… - Proceedings of the …, 1993 - National Acad Sciences
Nitric oxide (NO) in oxygen-containing aqueous solution has a short half-life that is often
attributed to a rapid oxidation to both NO2- and NO3-. The chemical fate of NO in aqueous …