We investigated the in vivo effects of orally administered cariprazine (RGH-188; trans-N-{4-[2-[4-(2,3-dichlorophenyl)-piperazin-1-yl]-ethyl]-cyclohexyl}-N′,N′-dimethyl-urea),
a D 3 /D …

Subnanomolar dopamine D3 receptor antagonism coupled to moderate D2 affinity results in
favourable antipsychotic-like activity in rodent models: II. behavioural characterisation of RG-…

Dopamine D 3 receptor partial agonism has been suggested as a potential therapeutic
intervention in cocaine addiction. RGH-237 [N-{4-[4-(3-aminocarbonyl-phenyl)-piperazin-1-yl]-…

RGH-1756, 1-(2-methoxy-phenyl)-4-{4-[4-(6-imidazol[2,1-b] thiazolyl)-phenoxy]-butyl-4- 14
C}-piperazine dimethane is a novel atypical antipsychotic drug candidate of Gedeon Richter …

Medicinal chemistry optimization of an impurity isolated during the scale-up synthesis of a
pyridylsulfonamide type dopamine D 3 /D 2 compound (1) led to a series of new piperazine …

… Dayong Li was involved with statistical analysis of study data. Adam Ruth was involved with
the analysis and interpretation of data and provided editorial support on the manuscript. All …

… Rui Li served as the study director and was involved in the conduct of the study and
collection of data. Dayong Li and Kaifeng Lu were involved in the study design, protocol …