hnRNP C increases amyloid precursor protein (APP) production by stabilizing APP mRNA

LE Rajagopalan, CJ Westmark… - Nucleic acids …, 1998 - academic.oup.com
We have previously shown that heterogeneous nuclear ribonucleoprotein C (hnRNP C) and
nucleolin bound specifically to a 29 nt sequence in the 3′-untranslated region of amyloid …

[HTML][HTML] Rho kinase-2 activation in human endothelial cells drives lysophosphatidic acid-mediated expression of cell adhesion molecules via NF-κB p65

H Shimada, LE Rajagopalan - Journal of biological chemistry, 2010 - ASBMB
Endothelial cells play an important role in the recruitment of immune cells to a disease locus
through the induced expression of chemokines and cell adhesion molecules (CAMs). The …

[HTML][HTML] Turnover and translation of in vitro synthesized messenger RNAs in transfected, normal cells

LE Rajagopalan, JS Malter - Journal of Biological Chemistry, 1996 - ASBMB
We have developed a novel system to examine intracellular mRNA decay pathways in the
absence of transcriptional blockade. In vitro transcribed, capped, and adenylated granulocyte-…

[HTML][HTML] Rho-kinase mediates lysophosphatidic acid-induced IL-8 and MCP-1 production via p38 and JNK pathways in human endothelial cells

H Shimada, LE Rajagopalan - FEBS letters, 2010 - Elsevier
Lysophosphatidic acid (LPA), an inflammatory mediator that is elevated in multiple
inflammatory diseases, is a potent activator of Rho kinase (ROCK) signaling and of chemokine …

TGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells

H Shimada, NR Staten, LE Rajagopalan - Journal of hepatology, 2011 - Elsevier
BACKGROUND & AIMS: TGF-β1 a key pro-fibrotic factor activates signaling via the canonical
ALK/SMAD as well as the Rho GTPase pathways. Rho kinase is a major downstream …

[HTML][HTML] Modulation of granulocyte-macrophage colony-stimulating factor mRNA stability in vitro by the adenosine-uridine binding factor.

LE Rajagopalan, JS Malter - Journal of Biological Chemistry, 1994 - Elsevier
In vitro decay of granulocyte-macrophage colony-stimulating factor (GM-CSF) mRNA was
examined on polysomes prepared from normal human peripheral blood mononuclear cells …

The prognostic value of pre-operative and post-operative B-type natriuretic peptides in patients undergoing noncardiac surgery: B-type natriuretic peptide and N …

…, F Puma, WB Pyun, M Radović, S Rajagopalan… - Journal of the American …, 2014 - jacc.org
Objectives : The objective of this study was to determine whether measuring post-operative
B-type natriuretic peptides (NPs) (ie, B-type natriuretic peptide [BNP] and N-terminal …

Growth factor‐mediated stabilization of amyloid precursor protein mRNA is mediated by a conserved 29‐nucleotide sequence in the 3′‐untranslated region

LE Rajagopalan, JS Malter - Journal of neurochemistry, 2000 - Wiley Online Library
Using a cell‐free translation system, we previously demonstrated that the turnover and translation
of amyloid precursor protein (APP) mRNA was regulated by a 29‐nucleotide instability …

Granulocyte-macrophage colony-stimulating factor mRNA stabilization enhances transgenic expression in normal cells and tissues

LE Rajagopalan, JK Burkholder, J Turner, J Culp… - 1995 - ashpublications.org
To increase transgenic production of granulocyte-macrophage colony-stimulating factor (GM-CSF),
we mutated the mRNA's 32-untranslated region, AUUUA instability elements. …

Postoperative B-type natriuretic peptide for prediction of major cardiac events in patients undergoing noncardiac surgery: systematic review and individual patient …

…, R Manikandan, WB Pyun, S Rajagopalan… - …, 2013 - pubs.asahq.org
Background: It is unclear whether postoperative B-type natriuretic peptides (ie, BNP and N-terminal
proBNP) can predict cardiovascular complications in noncardiac surgery. Methods: …