5-HT1F Receptor Agonists in Acute Migraine Treatment: A Hypothesis

NM Ramadan, V Skljarevski, LA Phebus… - …, 2003 - journals.sagepub.com
Serotonin-1F receptor (5-HT 1F ) agonists may relieve acute migraine without vasoconstriction.
We conducted a review of preclinical and clinical data that assessed the potential link …

Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease

…, DLG Nelson, S Luecke, LA Phebus… - Proceedings of the …, 2001 - National Acad Sciences
Parkinson's disease is a chronic neurodegenerative disorder characterized by the loss of
dopamine neurons in the substantia nigra, decreased striatal dopamine levels, and …

Measurement of striatal H2O2 by microdialysis following global forebrain ischemia and reperfusion in the rat: correlation with the cytotoxic potential of H2O2 in vitro

PA Hyslop, Z Zhang, DV Pearson, LA Phebus - Brain research, 1995 - Elsevier
… A dialysis probe with no exposed metal in the perfusion path was constructed essentially
as described by Phebus et al. [20]. At the time of 4-VO surgery, the probe was placed in the …

Serotonin in migraine: theories, animal models and emerging therapies

…, C Krieger, VM Kolb, KW Johnson, LA Phebus… - Progress in drug …, 1998 - Springer
A role for serotonin in migraine has been supported by changes in circulating levels of
serotonin and its metabolites during the phases of a migraine attack, along with the ability of …

Preclinical pharmacological profile of the selective 5-HT1F receptor agonist lasmiditan

DL Nelson, LA Phebus, KW Johnson… - …, 2010 - journals.sagepub.com
… The dural extravasation assay was modified from that previously described by Johnson and
Phebus (25). Male Wistar rats from Harlan Laboratories (250–350 g), fasted overnight, were …

Selective seratonin 1F (5-HT1F) receptor agonist LY334370 for acute migraine: a randomised controlled trial

…, KI Roon, WW Offen, NM Ramadan, LA Phebus… - The Lancet, 2001 - thelancet.com
Background Triptans (5-HT 1B/1D receptor agonists) are effective drugs for acute migraine,
but the side-effect of coronary vasoconstriction restricts their use in patients who are at risk of …

LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine

…, SD Silberstein, KW Johnson, LA Phebus… - …, 2004 - journals.sagepub.com
Glutamatergic hyperactivity is implicated migraine pathogenesis. Also, LY293558, an α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA)/kainate (KA) receptor antagonist, …

5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs

…, JM Zgombick, ML Cohen, TA Branchek, LA Phebus - …, 1997 - journals.lww.com
THE serotonin (5-HT) receptor subtype mediating inhibition of neurogenic dural inflammation
in guinea pigs was investigated using a series of serotonin agonists with differing affinities …

Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural …

LA Phebus, KW Johnson, JM Zgombick, PJ Gilbert… - Life sciences, 1997 - Elsevier
LY344864 is a selective receptor agonist with an affinity of 6 nM (K i ) at the recently cloned
5-HT 1F receptor. It possesses little affinity for the 56 other serotonergic and non-…