User profiles for Kyung Bo Kim
 | Kyung Bo KimFlorida International University Verified email at fiu.edu Cited by 8239 |
The ubiquitin‐proteasome pathway and proteasome inhibitors
The ubiquitin‐proteasome pathway has emerged as a central player in the regulation of several
diverse cellular processes. Here, we describe the important components of this complex …
diverse cellular processes. Here, we describe the important components of this complex …
Crystal structure of epoxomicin: 20S proteasome reveals a molecular basis for selectivity of α ', β '-epoxyketone proteasome inhibitors
In recent years, proteasome inhibitor development has received considerable interest given
the critical role of the proteasome in intracellular processes such as cell cycle progression, …
the critical role of the proteasome in intracellular processes such as cell cycle progression, …
[PDF][PDF] The tumor inhibitor and antiangiogenic agent withaferin A targets the intermediate filament protein vimentin
P Bargagna-Mohan, A Hamza, Y Kim, YKA Ho… - Chemistry & biology, 2007 - cell.com
The natural product withaferin A (WFA) exhibits antitumor and antiangiogenesis activity in
vivo, which results from this drug's potent growth inhibitory activities. Here, we show that WFA …
vivo, which results from this drug's potent growth inhibitory activities. Here, we show that WFA …
Total synthesis of the-potent proteasome inhibitor epoxomicin: a useful tool for understanding proteasome biology
N Sin, KB Kim, M Elofsson, L Meng, H Auth… - Bioorganic & medicinal …, 1999 - Elsevier
Epoxomicin (1), a peptide α',β'-epoxyketone isolated from the actinomycete strain No.Q996-17,
possesses potent in vivo anti-tumor and anti-inflammatory activities. In this paper, we …
possesses potent in vivo anti-tumor and anti-inflammatory activities. In this paper, we …
cGAS drives noncanonical-inflammasome activation in age-related macular degeneration
Geographic atrophy is a blinding form of age-related macular degeneration characterized
by retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency, …
by retinal pigmented epithelium (RPE) death; the RPE also exhibits DICER1 deficiency, …
Impact of linker length on the activity of PROTACs
Conventional genetic approaches have provided a powerful tool in the study of proteins.
However, these techniques often preclude selective manipulation of temporal and spatial …
However, these techniques often preclude selective manipulation of temporal and spatial …
Next-generation proteasome inhibitors for cancer therapy
Over 2 decades ago, the proteasome was considered a risky or even untenable therapeutic
target. Today, proteasome inhibitors are a mainstay in the treatment of multiple myeloma (…
target. Today, proteasome inhibitors are a mainstay in the treatment of multiple myeloma (…
Inhibitors of the immunoproteasome: current status and future directions
The ubiquitin-proteasome system (UPS) plays a vital role in maintaining protein homeostasis
and regulating numerous cellular processes. The proteasome, a multi-protease complex, is …
and regulating numerous cellular processes. The proteasome, a multi-protease complex, is …
Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes
Mammalian genomes encode seven catalytic proteasome subunits, namely, β1c, β2c, β5c (assembled
into constitutive 20S proteasome core particles), β1i, β2i, β5i (incorporated into …
into constitutive 20S proteasome core particles), β1i, β2i, β5i (incorporated into …
Proteasome inhibition by the natural products epoxomicin and dihydroeponemycin: insights into specificity and potency
While two structurally related epoxyketone-containing antitumor natural products, epoxomicin
and eponemycin, share the proteasome as a common intracellular target, they differ in …
and eponemycin, share the proteasome as a common intracellular target, they differ in …