User profiles for Kumar Sambamurti
Kumar SambamurtiProfessor of Neurosciences, Medical University of South Carolina Verified email at musc.edu Cited by 15445 |
Butyrylcholinesterase: an important new target in Alzheimer's disease therapy
Acetylcholinesterase (AChE) predominates in the healthy brain, with butyrylcholinesterase (BuChE)
considered to play a minor role in regulating brain acetylcholine (ACh) levels. …
considered to play a minor role in regulating brain acetylcholine (ACh) levels. …
Current drug targets for Alzheimer's disease treatment
…, MR Farlow, NH Greig, K Sambamurti - Drug development …, 2002 - Wiley Online Library
Alzheimer's disease (AD), the most common form of dementia among the elderly, is a
progressive, degenerative disorder of the brain with a loss of memory and cognition. A defining …
progressive, degenerative disorder of the brain with a loss of memory and cognition. A defining …
TNF-α inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets
D Tweedie, K Sambamurti… - Current Alzheimer …, 2007 - ingentaconnect.com
As the average ages of North Americans and Europeans continue to rise; similarly the
incidence of “old age” associated illnesses likewise increases. Most notably among these …
incidence of “old age” associated illnesses likewise increases. Most notably among these …
Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model
…, R Wang, GS Tint, K Sambamurti… - Neurobiology of …, 2000 - Elsevier
Recent data suggest that cholesterol metabolism is linked to susceptibility to Alzheimer's
disease (AD). However, no direct evidence has been reported linking cholesterol metabolism …
disease (AD). However, no direct evidence has been reported linking cholesterol metabolism …
Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer β-amyloid peptide in rodent
…, K Furukawa, K Sambamurti… - Proceedings of the …, 2005 - National Acad Sciences
Like acetylcholinesterase, butyrylcholinesterase (BChE) inactivates the neurotransmitter
acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is …
acetylcholine (ACh) and is hence a viable therapeutic target in Alzheimer's disease, which is …
GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism
…, H Shen, JM Egan, K Sambamurti… - Proceedings of the …, 2009 - National Acad Sciences
Glucagon-like peptide-1 (GLP-1) is an endogenous insulinotropic peptide secreted from the
gastrointestinal tract in response to food intake. It enhances pancreatic islet β-cell …
gastrointestinal tract in response to food intake. It enhances pancreatic islet β-cell …
[PDF][PDF] Increased App expression in a mouse model of Down's syndrome disrupts NGF transport and causes cholinergic neuron degeneration
…, R Takimoto-Kimura, AM Kleschevnikov, K Sambamurti… - Neuron, 2006 - cell.com
Degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive
dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and …
dysfunction in Alzheimer's disease (AD) and Down's syndrome (DS). We used Ts65Dn and …
Glucagon‐like peptide‐1 decreases endogenous amyloid‐β peptide (Aβ) levels and protects hippocampal neurons from death induced by Aβ and iron
TA Perry, DK Lahiri, K Sambamurti… - Journal of …, 2003 - Wiley Online Library
Glucagon‐like peptide‐1(7–36)‐amide (GLP‐1) is an endogenous insulinotropic peptide that
is secreted from the gastrointestinal tract in response to food. It enhances pancreatic islet β…
is secreted from the gastrointestinal tract in response to food. It enhances pancreatic islet β…
High cholesterol‐induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice
…, H Bimonte‐Nelson, K Sambamurti… - Journal of …, 2008 - Wiley Online Library
Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer’s
disease‐like dementia but the underlying mechanisms remain unknown. In this study, we …
disease‐like dementia but the underlying mechanisms remain unknown. In this study, we …
Amyloid-beta protein clearance and degradation (ABCD) pathways and their role in Alzheimer's disease
…, MA Pappolla, K Sambamurti - Current Alzheimer …, 2015 - ingentaconnect.com
Amyloid-β proteins (Aβ) of 42 (Aβ42) and 40 aa (Aβ40) accumulate as senile plaques (SP)
and cerebrovascular amyloid protein deposits that are defining diagnostic features of …
and cerebrovascular amyloid protein deposits that are defining diagnostic features of …