Insulin-like growth factors (IGF), IGF-I and IGF-II, are small polypeptides involved in regulating
cell proliferation, survival, differentiation, and transformation. IGF activities are mediated …

Dysregulated cellular apoptosis and resistance to cell death are hallmarks of neoplastic
initiation and disease progression. Therefore, the development of agents that overcome …

The RG7787 mesothelin-targeted recombinant immunotoxin (RIT) consists of an antibody
fragment targeting mesothelin (MSLN) fused to a 24-kD fragment of Pseudomonas exotoxin A …

A two component system, consisting of a fusion protein and an appropriate prodrug, suited
to perform selective tumor therapy in vivo is presented. The fusion protein, due to its …

A series of new prodrugs of daunorubicin and doxorubicin which are candidates for antibody-directed
enzyme prodrug therapy (ADEPT) is reported. These compounds (25a,b,c and 32a…

Loss of cell cycle control and tumor-induced neovascularization are major drivers of human
tumor growth. The multi-target tumor growth inhibitor ZK 304709 is a nanomolar inhibitor of …

Mesothelin overexpression in lung adenocarcinomas correlates with the presence of activating
KRAS mutations and poor prognosis. Hence SS1P, a mesothelin-targeted immunotoxin, …

HMR 1826 (N-[4-β-Glucuronyl-3-nitrobenzyl-oxycarbonyl]doxorubicin) is a nontoxic
glucuronide prodrug from which active doxorubicin is released by β-glucuronidase. Preclinical …

Glucuronidation of drugs represents a major pathway of human drug metabolism. Numerous
studies show that the glucuronides formed can accumulate during chronic therapy and/or …

Intrapancreatic tumor spread of ductal adenocarcinoma of head of pancreas was examined
histologically in 37 total pancreatectomy specimens. Five to 10 tissue blocks were prepared …