Therapeutic targeting of mitochondrial superoxide in hypertension

AE Dikalova, AT Bikineyeva, K Budzyn… - Circulation …, 2010 - Am Heart Assoc
Rationale: Superoxide ( ) has been implicated in the pathogenesis of many human diseases
including hypertension; however, commonly used antioxidants have proven ineffective in …

Partial carotid ligation is a model of acutely induced disturbed flow, leading to rapid endothelial dysfunction and atherosclerosis

…, CW Ni, A Rezvan, J Suo, K Budzyn… - American Journal …, 2009 - journals.physiology.org
Atherosclerosis is closely associated with disturbed flow characterized by low and oscillatory
shear stress, but studies directly linking disturbed flow to atherogenesis is lacking. The …

[HTML][HTML] Role of chemokine RANTES in the regulation of perivascular inflammation, T-cell accumulation, and vascular dysfunction in hypertension

…, R Nosalski, P Szczepaniak, K Budzyn… - The FASEB …, 2016 - ncbi.nlm.nih.gov
Recent studies have emphasized the role of perivascular inflammation in cardiovascular
disease. We studied mechanisms of perivascular leukocyte infiltration in angiotensin II (Ang II)-…

Targeting Rho and Rho-kinase in the treatment of cardiovascular disease

K Budzyn, PD Marley, CG Sobey - Trends in pharmacological sciences, 2006 - cell.com
The small GTPase Rho and its downstream effector Rho-kinase contribute to agonist-induced
vascular contraction via Ca 2+ sensitization. Reasonably selective pharmacological …

Reversal of vascular macrophage accumulation and hypertension by a CCR2 antagonist in deoxycorticosterone/salt-treated mice

CT Chan, JP Moore, K Budzyn, E Guida, H Diep… - …, 2012 - Am Heart Assoc
Infiltration of macrophages into the artery wall plays detrimental roles during hypertension
by promoting vascular inflammation and endothelial dysfunction, and it occurs via a chemo-…

A model of disturbed flow-induced atherosclerosis in mouse carotid artery by partial ligation and a simple method of RNA isolation from carotid endothelium

D Nam, CW Ni, A Rezvan, J Suo, K Budzyn… - JoVE (Journal of …, 2010 - jove.com
Despite the well-known close association, direct evidence linking disturbed flow to atherogenesis
has been lacking. We have recently used a modified version of carotid partial ligation …

Vascular dysfunction in cerebrovascular disease: mechanisms and therapeutic intervention

AA Miller, K Budzyn, CG Sobey - Clinical science, 2010 - portlandpress.com
The endothelium plays a crucial role in the control of vascular homoeostasis through maintaining
the synthesis of the vasoprotective molecule NO • (nitric oxide). Endothelial dysfunction …

Evidence that estrogen suppresses rho-kinase function in the cerebral circulation in vivo

S Chrissobolis, K Budzyn, PD Marley, CG Sobey - Stroke, 2004 - Am Heart Assoc
Background and Purpose— Premenopausal women are less susceptible to cardiovascular
diseases than men or postmenopausal women. Such disease states are often associated …

Segmental differences in the roles of rho-kinase and protein kinase C in mediating vasoconstriction

K Budzyn, M Paull, PD Marley, CG Sobey - Journal of Pharmacology and …, 2006 - ASPET
Rho-kinase and protein kinase C (PKC) have each been reported to mediate vasoconstriction
via calcium sensitization. However, the relative contributions of these two kinases to …

Opposing roles of endothelial and smooth muscle phosphatidylinositol 3-kinase in vasoconstriction: effects of rho-kinase and hypertension

K Budzyn, PD Marley, CG Sobey - Journal of Pharmacology and …, 2005 - ASPET
Phosphatidylinositol 3-kinase (PI3K) can activate endothelial nitric oxide synthase (eNOS),
leading to production of the vasodilator NO. In contrast, vascular smooth muscle (VSM) PI3K …