In recent years it has become apparent that sex is a major factor involved in modulating the
pharmacological effects of exogenous opioids. The kappa opioid receptor (KOPR) system is …

Repeated high dose (5.0 mg/kg) anabolic/androgenic steroid exposure during adolescence
stimulates offensive aggression in male Syrian hamsters. These studies examined whether …

Background We previously reported isolation of l-isocorypalmine (l-ICP), a mono-demethylated
analog of l-tetrahydropalmatine (l-THP), from the plant Corydalis yanhusuo. Here we …

We examined whether sex differences in κ-opioid receptor (KOPR) pharmacology exist in
guinea pigs, which are more similar to humans in the expression level and distribution of …

In the mouse 55C warm-water tail-withdrawal assay, a single administration of nor-binaltorphimine
(nor-BNI; 10 mg/kg ip) antagonized κ-opioid receptor (KOR) agonist-induced …

Chronic cocaine exposure in both human addicts and in rodent models of addiction reduces
prefrontal cortical activity, which subsequently dysregulates reward processing and higher …

Recently there has been a widespread interest in the development of kappa opioid receptor
(KOPR) ligands for treatment of pain, depression and anxiety, and prevention of stress-…

There is a growing body of evidence indicating that drug abuse is associated with escalated
states of aggressive responding. Considerable debate exists, however, regarding whether …

Activation of the Kappa Opioid Receptor (KOR) modulates dopamine (DA) signaling, and
Extracellular Regulated Kinase (ERK) Mitogen-Activated Protein (MAP) kinase activity, thereby …

… Then, comes my best friend Khampaseuth Rasakham and my mother Mala Thapa, two
women who only know how to give. They have only provided and sacrificed for others, their …