A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease‐relevant insults
…, M Kawasumi, M Nawa, K Terashita… - European Journal of …, 2003 - Wiley Online Library
Humanin (HN) is a newly identified neuroprotective peptide that specifically suppresses
Alzheimer's disease (AD)‐related neurotoxicity. HN peptide has been detected in the human AD …
Alzheimer's disease (AD)‐related neurotoxicity. HN peptide has been detected in the human AD …
Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults
…, T Niikura, Y Hashimoto, Y Ito, Y Kita, K Terashita… - Neuroscience …, 2002 - Elsevier
An unbiased functional screening with brain cDNA library from an Alzheimer's disease (AD)
brain identified a novel 24-residue peptide Humanin (HN), which suppresses AD-related …
brain identified a novel 24-residue peptide Humanin (HN), which suppresses AD-related …
Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of …
…, M Sato, J Sasabe, Y Kita, K Terashita… - Journal of …, 2005 - Soc Neuroscience
Alzheimer's disease (AD) is the most common cause of dementia. Humanin (HN) is a short
bioactive peptide abolishing neuronal cell death induced by various familial AD (FAD)-…
bioactive peptide abolishing neuronal cell death induced by various familial AD (FAD)-…
Involvement of c‐Jun N‐terminal kinase in amyloid precursor protein‐mediated neuronal cell death
…, E Tsukamoto, K Kouyama, K Terashita… - Journal of …, 2003 - Wiley Online Library
Amyloid precursor protein (APP), the precursor of Aβ, has been shown to function as a cell
surface receptor that mediates neuronal cell death by anti‐APP antibody. The c‐Jun N‐…
surface receptor that mediates neuronal cell death by anti‐APP antibody. The c‐Jun N‐…
Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease‐related neurotoxicity: functional potentiation by …
K Terashita, Y Hashimoto, T Niikura… - Journal of …, 2003 - Wiley Online Library
The 24‐residue peptide Humanin (HN), containing two Ser residues at positions 7 and 14,
protects neuronal cells from insults of various Alzheimer's disease (AD) genes and Aβ. It was …
protects neuronal cells from insults of various Alzheimer's disease (AD) genes and Aβ. It was …
Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal
…, K Kanekura, M Katada, M Ito, I Nishimoto, K Terashita… - Cellular signalling, 2007 - Elsevier
Frizzled-3 (Fzd3), highly expressed in both the central nervous system (CNS) and skin, plays
essential roles in axonal growth and guidance during the CNS development and may be …
essential roles in axonal growth and guidance during the CNS development and may be …
Implanted cannula-mediated repetitive administration of Aβ25–35 into the mouse cerebral ventricle effectively impairs spatial working memory
…, M Nawa, H Tajima, T Niikura, K Terashita… - Behavioural brain …, 2005 - Elsevier
Amyloid β (Aβ) is closely related to the onset of Alzheimer's disease (AD). To construct AD
animal models, a bolus administration of a large dose of toxic Aβ into the cerebral ventricles of …
animal models, a bolus administration of a large dose of toxic Aβ into the cerebral ventricles of …
[HTML][HTML] Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease
Humanin (HN) and its derivatives, such as Colivelin (CLN), suppress neuronal death
induced by insults related to Alzheimer's disease (AD) by activating STAT3 in vitro. They also …
induced by insults related to Alzheimer's disease (AD) by activating STAT3 in vitro. They also …
Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein …
…, M Kawasumi, T Hiraki, Y Kita, K Terashita… - Journal of …, 2001 - Soc Neuroscience
It has been found that insulin-like growth factor I (IGF-I) exerts cytoprotection against Aβ
amyloid-induced neuronal cell death. Deposits of Aβ amyloid are one of the pathological …
amyloid-induced neuronal cell death. Deposits of Aβ amyloid are one of the pathological …
The cytoplasmic domain of Alzheimer's amyloid-β protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated …
…, M Ishizaka, M Yamada, M Nawa, K Terashita… - … of Pharmacology and …, 2003 - ASPET
The biological function of full-length amyloid-β protein precursor (AβPP), the precursor of Aβ,
is not fully understood. Multiple laboratories have reported that antibody binding to cell …
is not fully understood. Multiple laboratories have reported that antibody binding to cell …