Background: While tumour necrosis factor α (TNF-α) appears to be associated with the
development of non-alcoholic steatohepatitis (NASH), its precise role in the pathogenesis of …

Although nonalcoholic steatohepatitis (NASH) is associated with hypercholesterolemia, the
underlying mechanisms of this association have not been clarified. We aimed to elucidate …

BACKGROUND & AIMS: Some studies have indicated that dietary cholesterol has a role in
the progression of liver fibrosis. We investigated the mechanisms by which dietary cholesterol …

BACKGROUND & AIMS: The tumor suppressor p53 is a primary sensor of stressful stimuli,
controlling a number of biologic processes. The aim of our study was to examine the roles of …

It is unclear how hepatic adiponectin resistance and sensitivity mediated by the adiponectin
receptor, AdipoR2, contributes to the progression of nonalcoholic steatohepatitis (NASH). …

Lipocalin-type prostaglandin D synthase (L-PGDS), which was originally identified as an
enzyme responsible for PGD 2 biosynthesis in the brain, is highly expressed in the myocardium…

E3 ubiquitin ligase complexes of the SCF type consist of ring-box 1 (Rbx1), cullin 1 (Cul1), S-phase
kinase-associated protein 1 (Skp1), and a member of the F-box family of proteins. …

Background & Aims : Treatment of steatosis is important in preventing development of fibrosis
in alcoholic liver diseases. This study aimed to examine if pioglitazone, an antidiabetic …

Background First reported in 1955, Cronkhite–Canada syndrome (CCS), a rare syndrome
characterized by ectodermal abnormalities and inflammatory changes of the gastrointestinal …

Background: Previous work with metformin has shown that this antidiabetic agent improves
nonalcoholic fatty liver in ob/ob mice. AMP‐activated protein kinase (AMPK) is one of the …