User profiles for Ken-ichi Ogawara
Ken-ichi OgawaraKobe Pharmaceutical University Verified email at kobepharma-u.ac.jp Cited by 4332 |
Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics
S Nagayama, K Ogawara, Y Fukuoka, K Higaki… - International journal of …, 2007 - Elsevier
The relationship between the time-dependent change in serum proteins adsorbed on
nanoparticles and their disposition to the liver was investigated by employing lecithin-coated …
nanoparticles and their disposition to the liver was investigated by employing lecithin-coated …
Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles
K Ogawara, K Furumoto, S Nagayama, K Minato… - Journal of controlled …, 2004 - Elsevier
We evaluated the in vivo disposition characteristics of polystyrene nanospheres (NS) with
the particle size of 50 nm (NS-50) pre-coated with human serum albumin (HSA) after …
the particle size of 50 nm (NS-50) pre-coated with human serum albumin (HSA) after …
Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use
C Amnuaikit, I Ikeuchi, K Ogawara, K Higaki… - International journal of …, 2005 - Elsevier
To develop the suitable film formulations of propranolol hydrochloride (PPL) containing
enhancers for transdermal use, polymeric film formulations were prepared by employing ethyl …
enhancers for transdermal use, polymeric film formulations were prepared by employing ethyl …
Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers
The objective of this study is to evaluate the biodistribution characteristics of liposomes
surface-modified with the mixture of polyethylene glycol (PEG) and polyvinyl alcohol (PVA) as a …
surface-modified with the mixture of polyethylene glycol (PEG) and polyvinyl alcohol (PVA) as a …
PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy
Y Yoshizawa, Y Kono, K Ogawara, T Kimura… - International journal of …, 2011 - Elsevier
To find out potent paclitaxel (PTX) formulations for cancer chemotherapy, we formulated
PTX in O/W emulsion and liposome selected as candidates of nanocarriers for PTX. Surface …
PTX in O/W emulsion and liposome selected as candidates of nanocarriers for PTX. Surface …
Hepatic uptake of polystyrene microspheres in rats: effect of particle size on intrahepatic distribution
K Ogawara, M Yoshida, K Higaki, T Kimura… - Journal of Controlled …, 1999 - Elsevier
The in vivo disposition of polystyrene microsphere (MS) with the particle size of 50 nm (MS-50)
or 500 nm (MS-500) was characterized after intravenous administration to rats. A rapid …
or 500 nm (MS-500) was characterized after intravenous administration to rats. A rapid …
In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice: Involvement of cytotoxic effect on vascular endothelial cells
K Ogawara, K Un, K Tanaka, K Higaki… - Journal of controlled …, 2009 - Elsevier
We evaluated the in vivo anti-tumor effect of polyethylene glycol-modified liposomal
doxorubicin (PEG liposomal DOX) in the DOX-resistant Colon-26 cancer cells (C26/DOX)-bearing …
doxorubicin (PEG liposomal DOX) in the DOX-resistant Colon-26 cancer cells (C26/DOX)-bearing …
Determinants for in vivo anti-tumor effects of PEG liposomal doxorubicin: importance of vascular permeability within tumors
K Ogawara, K Un, K Minato, K Tanaka, K Higaki… - International journal of …, 2008 - Elsevier
To elucidate the determinants of the in vivo anti-tumor efficacy of polyethylene glycol (PEG)-modified
liposomal doxorubicin (DOX), we examined its anti-tumor effect against three …
liposomal doxorubicin (DOX), we examined its anti-tumor effect against three …
A Novel Strategy to Modify Adenovirus Tropism and Enhance Transgene Delivery to Activated Vascular Endothelial Cells In Vitro and In Vivo
To assess the possibilities of retargeting adenovirus to activated endothelial cells, we
conjugated bifunctional polyethylene glycol (PEG) onto the adenoviral capsid to inhibit the …
conjugated bifunctional polyethylene glycol (PEG) onto the adenoviral capsid to inhibit the …
Nanoparticle-based photodynamic therapy: current status and future application to improve outcomes of cancer treatment
K Ogawara, K Higaki - Chemical and Pharmaceutical Bulletin, 2017 - jstage.jst.go.jp
Photodynamic therapy (PDT) is an emerging cancer treatment that uses photosensitizers (PS),
along with light to activate them, resulting in oxidation of various biological components in …
along with light to activate them, resulting in oxidation of various biological components in …