User profiles for Ken-ichi Ogawara

Ken-ichi Ogawara

Kobe Pharmaceutical University
Verified email at kobepharma-u.ac.jp
Cited by 4332

Time-dependent changes in opsonin amount associated on nanoparticles alter their hepatic uptake characteristics

S Nagayama, K Ogawara, Y Fukuoka, K Higaki… - International journal of …, 2007 - Elsevier
The relationship between the time-dependent change in serum proteins adsorbed on
nanoparticles and their disposition to the liver was investigated by employing lecithin-coated …

Pre-coating with serum albumin reduces receptor-mediated hepatic disposition of polystyrene nanosphere: implications for rational design of nanoparticles

K Ogawara, K Furumoto, S Nagayama, K Minato… - Journal of controlled …, 2004 - Elsevier
We evaluated the in vivo disposition characteristics of polystyrene nanospheres (NS) with
the particle size of 50 nm (NS-50) pre-coated with human serum albumin (HSA) after …

Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use

C Amnuaikit, I Ikeuchi, K Ogawara, K Higaki… - International journal of …, 2005 - Elsevier
To develop the suitable film formulations of propranolol hydrochloride (PPL) containing
enhancers for transdermal use, polymeric film formulations were prepared by employing ethyl …

Prolongation of residence time of liposome by surface-modification with mixture of hydrophilic polymers

T Shehata, K Ogawara, K Higaki, T Kimura - International journal of …, 2008 - Elsevier
The objective of this study is to evaluate the biodistribution characteristics of liposomes
surface-modified with the mixture of polyethylene glycol (PEG) and polyvinyl alcohol (PVA) as a …

PEG liposomalization of paclitaxel improved its in vivo disposition and anti-tumor efficacy

Y Yoshizawa, Y Kono, K Ogawara, T Kimura… - International journal of …, 2011 - Elsevier
To find out potent paclitaxel (PTX) formulations for cancer chemotherapy, we formulated
PTX in O/W emulsion and liposome selected as candidates of nanocarriers for PTX. Surface …

Hepatic uptake of polystyrene microspheres in rats: effect of particle size on intrahepatic distribution

K Ogawara, M Yoshida, K Higaki, T Kimura… - Journal of Controlled …, 1999 - Elsevier
The in vivo disposition of polystyrene microsphere (MS) with the particle size of 50 nm (MS-50)
or 500 nm (MS-500) was characterized after intravenous administration to rats. A rapid …

In vivo anti-tumor effect of PEG liposomal doxorubicin (DOX) in DOX-resistant tumor-bearing mice: Involvement of cytotoxic effect on vascular endothelial cells

K Ogawara, K Un, K Tanaka, K Higaki… - Journal of controlled …, 2009 - Elsevier
We evaluated the in vivo anti-tumor effect of polyethylene glycol-modified liposomal
doxorubicin (PEG liposomal DOX) in the DOX-resistant Colon-26 cancer cells (C26/DOX)-bearing …

Determinants for in vivo anti-tumor effects of PEG liposomal doxorubicin: importance of vascular permeability within tumors

K Ogawara, K Un, K Minato, K Tanaka, K Higaki… - International journal of …, 2008 - Elsevier
To elucidate the determinants of the in vivo anti-tumor efficacy of polyethylene glycol (PEG)-modified
liposomal doxorubicin (DOX), we examined its anti-tumor effect against three …

A Novel Strategy to Modify Adenovirus Tropism and Enhance Transgene Delivery to Activated Vascular Endothelial Cells In Vitro and In Vivo

K Ogawara, MG Rots, RJ Kok, HE Moorlag… - Human gene …, 2004 - liebertpub.com
To assess the possibilities of retargeting adenovirus to activated endothelial cells, we
conjugated bifunctional polyethylene glycol (PEG) onto the adenoviral capsid to inhibit the …

Nanoparticle-based photodynamic therapy: current status and future application to improve outcomes of cancer treatment

K Ogawara, K Higaki - Chemical and Pharmaceutical Bulletin, 2017 - jstage.jst.go.jp
Photodynamic therapy (PDT) is an emerging cancer treatment that uses photosensitizers (PS),
along with light to activate them, resulting in oxidation of various biological components in …