The Na-glucose cotransporter SGLT2 mediates high-capacity glucose uptake in the early
proximal tubule and SGLT2 inhibitors are developed as new antidiabetic drugs. We used gene-…

TLR-induced innate immunity and inflammation are mediated by signaling cascades leading
to activation of the MAPK family of Ser/Thr protein kinases, including p38 MAPK, which …

In the kidney, the sodium-glucose cotransporters SGLT2 and SGLT1 are thought to account
for >90 and ∼3% of fractional glucose reabsorption (FGR), respectively. However, …

The development of the humoral immune response against porcine reproductive and
respiratory syndrome (PRRS) virus was monitored by an indirect fluorescent antibody (IFA) test, …

The vertebrate zinc finger genes of the Gli family are homologs of the Drosophila gene
cubitus interruptus. In frog embryos, Gli1 is expressed transiently in the prospective floor plate …

Induction of the floor plate at the ventral midline of the neural tube is one of the earliest events
in the establishment of dorsoventral (d/v) polarity in the vertebrate central nervous system (…

Mutations in the gene encoding for the Na+-glucose co-transporter SGLT2 (SLC5A2)
associate with familial renal glucosuria, but the role of SGLT2 in the kidney is incompletely …

Three mouse genes, Gli, Gli-2, and Gli-3, which share a similar zinc finger domain with the
products of the Drosophila segment polarity gene cubitus interruptus and the Caenorhabditis …

5-Hydroxytryptamine (serotonin) (5-HT) is a neurotransmitter with both central and peripheral
functions, including the modulation of mood, appetite, hemodynamics, gastrointestinal (GI) …

Large collections of knockout organisms facilitate the elucidation of gene functions. Here we
used retroviral insertion or homologous recombination to disrupt 472 genes encoding …