Antivascular and antitumor evaluation of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes, a novel series of anticancer agents

…, L Leblond, B Hamelin, C Desputeau, K Dong… - Molecular cancer …, 2004 - AACR
A novel series of 2-amino-4-(3-bromo-4,5-dimethoxy-phenyl)-3-cyano-4H-chromenes was
identified as potent apoptosis inducers through a cell-based high throughput screening assay…

UV‐induced DNA damage initiates release of MMP‐1 in human skin

KK Dong, N Damaghi, SD Picart… - Experimental …, 2008 - Wiley Online Library
Destruction of collagen is a hallmark of photoaging. The major enzyme responsible for collagen
1 digestion, matrix metalloproteinase‐1 (MMP‐1), is induced by exposure to sunlight. To …

[HTML][HTML] Biological rhythms in the skin

MS Matsui, E Pelle, K Dong, N Pernodet - International journal of …, 2016 - mdpi.com
Circadian rhythms, ≈24 h oscillations in behavior and physiology, are reflected in all cells
of the body and function to optimize cellular functions and meet environmental challenges …

Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system

NG Markova, N Karaman-Jurukovska, KK Dong… - Free Radical Biology …, 2009 - Elsevier
The cellular defense system against harmful levels of reactive oxygen species consists of
antioxidant enzymatic activities and small nonenzymatic molecules. l-Ergothioneine has long …

Stability: recommendation for best practices and harmonization from the Global Bioanalysis Consortium Harmonization Team

…, M Yadav, Y Ohtsu, J White, MF Riccio, K Dong… - The AAPS Journal, 2014 - Springer
This paper provides a comprehensive overview of stability-related aspects of quantitative
bioanalysis and recommends science-based best practices, covering small and large …

Prediction of brain: blood unbound concentration ratios in CNS drug discovery employing in silico and in vitro model systems

H Liu, K Dong, W Zhang, SG Summerfield… - Drug discovery today, 2018 - Elsevier
Highlights • Increase in K p, uu, br/CL int translates into higher drug brain unbound
exposure • The performance of current in silico K p, uu, br models is moderate • A deep …

[HTML][HTML] Age associated decrease of MT-1 melatonin receptor in human dermal skin fibroblasts impairs protection against UV-induced DNA damage

K Dong, E Goyarts, A Rella, E Pelle, YH Wong… - International journal of …, 2020 - mdpi.com
The human body follows a physiological rhythm in response to the day/night cycle which is
synchronized with the circadian rhythm through internal clocks. Most cells in the human body, …

How is patient‐centred care conceptualized in obstetrical health? comparison of themes from concept analyses in obstetrical health‐and patient‐centred care

K Dong, B Jameel, AR Gagliardi - Health Expectations, 2022 - Wiley Online Library
Background Due to gender inequities that exist for women of childbearing age, there exists
a need to deliver care tailored to their needs and preferences. Patient‐centred care (PCC) …

Effects of ozone in normal human epidermal keratinocytes

JT McCarthy, E Pelle, K Dong… - Experimental …, 2013 - Wiley Online Library
Ozone is a tropospheric pollutant that can form at ground level as a result of an interaction
between sunlight and hydrocarbon engine emissions. As ozone is an extremely oxidative …

Drug distribution into peripheral nerve

…, X Yu, Z Wan, J Wang, SG Summerfield, K Dong… - … of Pharmacology and …, 2018 - ASPET
Little is known about the impact of the blood–nerve barrier (BNB) on drug distribution into
peripheral nerves. In this study, we examined the peripheral nerve penetration in rats of 11 …