The gastric HK-ATPase: structure, function, and inhibition

JM Shin, K Munson, O Vagin, G Sachs - Pflügers Archiv-European Journal …, 2009 - Springer
The gastric H,K-ATPase, a member of the P 2 -type ATPase family, is the integral membrane
protein responsible for gastric acid secretion. It is an α,β-heterodimeric enzyme that …

The gastric H, K ATPase as a drug target: past, present, and future

…, N Lambrecht, I Yakubov, K Munson - Journal of clinical …, 2007 - journals.lww.com
The recent progress in therapy if acid disease has relied heavily on the performance of drugs
targeted against the H, K ATPase of the stomach and the H2 receptor antagonists. It has …

Distinct classes of proteasome-modulating agents cooperatively augment recombinant adeno-associated virus type 2 and type 5-mediated transduction from the …

…, R Zak, Y Zhang, W Ding, S Godwin, K Munson… - Journal of …, 2004 - Am Soc Microbiol
Tripeptidyl aldehyde proteasome inhibitors have been shown to effectively increase viral
capsid ubiquitination and transduction of recombinant adeno-associated virus type 2 (rAAV-2) …

Characterization of a novel potassium-competitive acid blocker of the gastric H, K-ATPase, 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N …

JM Shin, N Inatomi, K Munson, D Strugatsky… - … of Pharmacology and …, 2011 - ASPET
Inhibition of the gastric H,K-ATPase by the potassium-competitive acid blocker (P-CAB) 1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine
(TAK-438), is …

Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori

D Strugatsky, R McNulty, K Munson, CK Chen… - Nature, 2013 - nature.com
Half the world’s population is chronically infected with Helicobacter pylori 1 , causing
gastritis, gastric ulcers and an increased incidence of gastric adenocarcinoma 2 . Its proton-gated …

Diverticulitis: a comprehensive follow-up

KD Munson, MA Hensien, LN Jacob… - Diseases of the colon …, 1996 - journals.lww.com
PURPOSE: This study was undertaken to examine the longterm results of medical and surgical
management for diverticulitis. METHODS: A retrospective review of all patients admitted …

The binding selectivity of vonoprazan (TAK‐438) to the gastric H+,K+‐ATPase

DR Scott, KB Munson, EA Marcus… - Alimentary …, 2015 - Wiley Online Library
Background The gastric H + ,K + ‐ ATP ase is the preferred target for acid suppression. Until
recently, the only drugs that effectively inhibited this ATP ase were the proton pump …

Transduction of nonhuman primate brain with adeno-associated virus serotype 1: vector trafficking and immune response

P Hadaczek, J Forsayeth, H Mirek, K Munson… - Human gene …, 2009 - liebertpub.com
We used convection-enhanced delivery (CED) to characterize gene delivery mediated by
adeno-associated virus type 1 (AAV1) by tracking expression of hrGFP (humanized green …

Inhibitor and ion binding sites on the gastric H, K-ATPase

K Munson, R Garcia, G Sachs - Biochemistry, 2005 - ACS Publications
The gastric H,K-ATPase catalyzes electroneutral exchange of H + for K + as a function of
enzyme phosphorylation and dephosphorylation during transition between E 1 /E 1 -P (ion site …

Membrane topology and omeprazole labeling of the gastric hydrogen ion-potassium-adenosinetriphosphatase

M Besancon, JM Shin, F Mercier, K Munson… - Biochemistry, 1993 - ACS Publications
Revised Manuscript Received December 8, 1992 abstract: The gastric H+, K+-ATPase is an
a/3 heterodimer with close homology to the Na+, K+-ATPase. Digestion of intactcytoplasmic-…