Oxaliplatin, an effective cytotoxic treatment in combination with 5‐fluorouracil for colorectal
cancer, is associated with sensory, motor and autonomic neurotoxicity. Motor symptoms …

The detection of several different neurotransmitters with the same sensor in real-time would
be a powerful asset to the field of neurochemistry. We have developed a detector for a broad …

We developed and validated a new optical mapping system for quantification of electrical
activation and repolarisation in murine atria. The system makes use of a novel 2nd generation …

Nerve terminals contain multiple sites specialized for the release of neurotransmitters. Release
usually occurs with low probability, a design thought to confer many advantages. High-…

Background The left atrial posterior wall (LAPW) is potentially an important area for the
development and maintenance of atrial fibrillation. We assessed whether there are regional …

A confocal Ca 2+ imaging technique has been used to detect ATP release from individual
sympathetic varicosities on the same nerve terminal branch. Varicose nerve terminals and …

Spontaneous purinergic neurotransmission was characterized in the mouse urinary bladder,
a model for the pathological or ageing human bladder. Intracellular electrophysiological …

Background: Despite the rarity of pheochromocytoma, diagnosis is important because of the
dangers of uncontrolled severe hypertension and the availability of very effective surgical …

While nicotine is known to act at neuronal nicotinic acetylcholine receptors (nAChRs) to facilitate
neurotransmitter release, the mechanisms underlying this action are poorly understood. …

1 1. Action potential‐evoked Ca 2+ transients in postganglionic sympathetic axon bundles
in mouse vas deferens have been characterized using confocal microscopy and Ca 2+ …