3. Morbidity and mortality rates due to diseases such as stroke, myocardial infarction, heart
disease and chronic renal disease increase with elevating blood pressure. The effects of …

… Kazuaki Shimamoto, Katsuyuki Ando, Toshiro Fujita, Naoyuki Hasebe, Jitsuo Higaki,
Masatsugu Horiuchi, Yutaka Imai, Tsutomu Imaizumi, Toshihiko Ishimitsu, Masaaki Ito …

Sir2 (silent information regulator 2) is an NAD + -dependent histone deacetylase that
contributes to longevity in yeast. SIRT1, a mammalian Sir2 ortholog, deacetylates histones and …

Adiponectin, an adipocyte-derived protein, has been suggested to play an important role in
insulin sensitivity. We examined the association between insulin sensitivity (M value) …

Over the past decade, evidences of an integration of metabolic and inflammatory pathways,
referred to as metaflammation in several aspects of metabolic syndrome, have been …

In this prospective, randomized, open-label, blinded end point study, we aimed to establish
whether strict blood pressure control (<140 mm Hg) is superior to moderate blood pressure …

Oxidative stress plays a pivotal role in chronic heart failure. SIRT1, an NAD + -dependent
histone/protein deacetylase, promotes cell survival under oxidative stress when it is expressed …

Background The increased prevalence of type 2 diabetes mellitus is a major concern for
health providers. We therefore assessed whether voglibose, an α-glucosidase inhibitor, could …

BACKGROUND Angiotensin-converting enzyme 2 (ACE2) is highly expressed in the kidney
and converts angiotensin (Ang) II to Ang-(1–7), a renoprotective peptide. Urinary ACE2 has …

Strain rate (SR) imaging enables quantitative measurement of left ventricular (LV) function
independent of cardiac translation. However, whether SR imaging is applicable for detection …