New insights into β‐adrenoceptors in smooth muscle: Distribution of receptor subtypes and molecular mechanisms triggering muscle relaxation
Y Tanaka, T Horinouchi, K Koike - Clinical and Experimental …, 2005 - Wiley Online Library
The β‐adrenoceptor is currently classified into β 1 , β 2 and β 3 subtypes and all three
subtypes are expressed in smooth muscle. Each β‐adrenoceptor subtype exhibits tissue‐specific …
subtypes are expressed in smooth muscle. Each β‐adrenoceptor subtype exhibits tissue‐specific …
MaxiK channel roles in blood vessel relaxations induced by endothelium-derived relaxing factors and their molecular mechanisms
Y Tanaka, K Koike, L Toro - Journal of Smooth Muscle Research, 2004 - jstage.jst.go.jp
The endothelium of blood vessels plays a crucial role in the regulation of blood flow by
controlling mechanical functions of underlying vascular smooth muscle. The regulation by the …
controlling mechanical functions of underlying vascular smooth muscle. The regulation by the …
New insights into the intracellular mechanisms by which PGI2 analogues elicit vascular relaxation: cyclic AMP-independent, Gs-protein mediated-activation of MaxiK …
Y Tanaka, F Yamaki, K Koike… - … & Hematological Agents, 2004 - ingentaconnect.com
Prostaglandin I2 (PGI2, prostacyclin), an eicosanoid of the cyclooxygenase pathway,
causes relaxation of vascular smooth muscle in most blood vessels and inhibits platelet …
causes relaxation of vascular smooth muscle in most blood vessels and inhibits platelet …
Kv channels contribute to nitric oxide-and atrial natriuretic peptide-induced relaxation of a rat conduit artery
…, M Song, K Nishimaru, K Shigenobu, K Koike… - … of Pharmacology and …, 2006 - ASPET
The role of K + channels in nitric oxide (NO)-induced vasorelaxation has been largely
investigated in resistance vessels where iberiotoxin-sensitive MaxiK channels play a predominant …
investigated in resistance vessels where iberiotoxin-sensitive MaxiK channels play a predominant …
β1-subunit of MaxiK channel in smooth muscle: a key molecule which tunes muscle mechanical activity
Y Tanaka, K Koike, A Alioua, K Shigenobu… - Journal of …, 2004 - Elsevier
The MaxiK channel is the large-conductance, voltage-dependent, and Ca 2+ -activated K +
channel. This channel is almost ubiquitously distributed among mammalian tissues including …
channel. This channel is almost ubiquitously distributed among mammalian tissues including …
Proliferative effects of angiotensin II and endothelin-1 on guinea pig gingival fibroblast cells in culture
N Ohuchi, K Koike, M Sano, T Kusama… - … and Physiology Part C …, 2002 - Elsevier
We investigated whether phenytoin (PHT) and nifedipine (NIF) induce angiotensin II (Ang II)
and endothelin-1 (ET-1) generation by cultured gingival fibroblasts derived from guinea pigs …
and endothelin-1 (ET-1) generation by cultured gingival fibroblasts derived from guinea pigs …
Nitric oxide (NO) primarily accounts for endothelium-dependent component of β-adrenoceptor-activated smooth muscle relaxation of mouse aorta in response to …
…, T Okamoto, F Yamaki, Y Tanaka, K Koike - Journal of Smooth …, 2002 - jstage.jst.go.jp
Isoprenaline is known to produce vascular relaxation through activation of β-adrenoceptors.
In recent years, β-adrenoceptor-activated vascular relaxation has been the focus of …
In recent years, β-adrenoceptor-activated vascular relaxation has been the focus of …
Correlation between vasoconstrictor roles and mRNA expression of α1‐adrenoceptor subtypes in blood vessels of genetically engineered mice
…, T Kitamura, G Tsujimoto, K Koike - British journal of …, 2005 - Wiley Online Library
We examined the contribution of each α 1 ‐adrenoceptor (AR) subtype in noradrenaline (NAd)‐evoked
contraction in the thoracic aortas and mesenteric arteries of mice. Compared with …
contraction in the thoracic aortas and mesenteric arteries of mice. Compared with …
MaxiK channel-mediated relaxation of guinea-pig aorta following stimulation of IP receptor with beraprost via cyclic AMP-dependent and-independent mechanisms
…, M Kaga, T Horinouchi, H Tanaka, K Koike… - Naunyn-Schmiedeberg's …, 2001 - Springer
The present study was aimed to elucidate the cellular pathway(s) controlling vascular
relaxation triggered by stimulation of prostaglandin I 2 (PGI 2 , IP) receptor with a stable PGI 2 …
relaxation triggered by stimulation of prostaglandin I 2 (PGI 2 , IP) receptor with a stable PGI 2 …
Functional contribution of voltage-dependent and Ca2+-activated K+ (BKCa) channels to the relaxation of guinea-pig aorta in response to natriuretic peptides
K Otsuka, H Tanaka, T Horinouchi, K Koike… - Journal of Smooth …, 2002 - jstage.jst.go.jp
We examined the relaxant effects of natriuretic peptide family on the isolated guinea-pig aorta
to determine the receptor subtype which primarily mediates this vascular relaxation, with …
to determine the receptor subtype which primarily mediates this vascular relaxation, with …