The mechanism for the accumulation of itraconazole (ITZ) in its elimination from the brain
was studied in rats and mice. The concentration of ITZ in liver tissue declined in parallel with …

The extent of decreases in apparent hepatic clearance and intrinsic hepatic clearance of
midazolam (MDZ) after intravenous administration of MDZ with concomitant oral administration …

To evaluate the extent of drug-drug interaction concerning metabolic inhibition in the liver
quantitatively, we tried to predict the plasma concentration increasing ratio of midazolam (MDZ…

Glucuronidation via UDP-glucuronosyltransferase (UGT) in the intestine has been reported
to influence the pharmacokinetics (PK) of drugs; however, information concerning the …

To evaluate the degree of drug-drug interaction concerning metabolic inhibition in the liver
quantitatively, we tried to predict the plasma concentration increasing ratio (R) of midazolam (…

Dotinurad, a novel selective urate reabsorption inhibitor, is used to treat hyperuricemia. In
humans, orally administered dotinurad is excreted mainly as glucuronide and sulfate …

To predict the degree of accumulation of hepatic metabolic inhibitors in the liver from the in
vitro data, we investigated the relationship between cell/medium concentration ratios (C/M …

UDP-glucuronosyltransferase (UGT) is highly expressed in the small intestine and catalyzes
the glucuronidation of small molecules, which may affect the oral bioavailability of drugs. …

We investigated whether the effects of intestinal glucuronidation on the first-pass effect can
be predicted from in vitro data for UDP-glucuronosyltransferase (UGT) substrates. Human in …

As intestinal glucuronidation has been suggested to generate the low oral bioavailability (F)
of drugs, estimating its effects would be valuable for selecting drug candidates. Here, we …