The T-helper cell type 1 immune response to gram-negative bacterial infections is impaired in COPD
J Knobloch, K Schild, D Jungck, K Urban… - American journal of …, 2011 - atsjournals.org
Rationale: The increased susceptibility to bacterial infections in chronic obstructive pulmonary
disease (COPD) is critical for exacerbations. Toll-like receptor-4 (TLR4) detects bacteria …
disease (COPD) is critical for exacerbations. Toll-like receptor-4 (TLR4) detects bacteria …
Resveratrol impairs the release of steroid-resistant inflammatory cytokines from human airway smooth muscle cells in chronic obstructive pulmonary disease
J Knobloch, B Sibbing, D Jungck, Y Lin, K Urban… - … of Pharmacology and …, 2010 - ASPET
Chronic obstructive pulmonary disease (COPD) therapy is complicated by corticosteroid
resistance of the interleukin 8 (IL-8)-dependent and granulocyte macrophage-colony stimulating …
resistance of the interleukin 8 (IL-8)-dependent and granulocyte macrophage-colony stimulating …
[HTML][HTML] CAR T cells as micropharmacies against solid cancers: Combining effector T-cell mediated cell death with vascular targeting in a one-step engineering …
…, M Flügge, J Meltzer, L Greune, K Urban… - Cancer Gene …, 2023 - nature.com
To enhance the potency of chimeric antigen receptor (CAR) engineered T cells in solid
cancers, we designed a novel cell-based combination strategy with an additional therapeutic …
cancers, we designed a novel cell-based combination strategy with an additional therapeutic …
Resveratrol impairs the release of steroid‐resistant cytokines from bacterial endotoxin‐exposed alveolar macrophages in chronic obstructive pulmonary disease
…, H Hag, D Jungck, K Urban… - Basic & clinical …, 2011 - Wiley Online Library
Airway inflammation in chronic obstructive pulmonary disease (COPD) is believed to be
insensitive to corticosteroids. However, corticosteroids are recommended in COPD (GOLD …
insensitive to corticosteroids. However, corticosteroids are recommended in COPD (GOLD …
[HTML][HTML] Caenorhabditis elegans P5B-type ATPase CATP-5 operates in polyamine transport and is crucial for norspermidine-mediated suppression of RNA …
A Heinick, K Urban, S Roth, D Spies, F Nunes… - The FASEB …, 2010 - ncbi.nlm.nih.gov
Physiological polyamines are required in various biological processes. In the current study,
we used norspermidine, a structural analog of the natural polyamine spermidine, to …
we used norspermidine, a structural analog of the natural polyamine spermidine, to …
[HTML][HTML] HLA-G and HLA-E immune checkpoints are widely expressed in Ewing sarcoma but have limited functional impact on the effector functions of antigen-specific …
B Altvater, S Kailayangiri, LF Pérez Lanuza, K Urban… - Cancers, 2021 - mdpi.com
Simple Summary Solid cancers can effectively counteract immune attack by inhibitory
checkpoints in the tumor microenvironment. Blockade of relevant immune checkpoints could be a …
checkpoints in the tumor microenvironment. Blockade of relevant immune checkpoints could be a …
From early embryonic to adult stage: comparative study of action potentials of native and pluripotent stem cell-derived cardiomyocytes
G Peinkofer, K Burkert, K Urban… - Stem Cells and …, 2016 - liebertpub.com
Cardiomyocytes (CMs) derived from induced pluripotent stem cells (iPS-CMs) are promising
candidates for cell therapy, drug screening, and developmental studies. It is known that iPS-…
candidates for cell therapy, drug screening, and developmental studies. It is known that iPS-…
IL-5 release of CD4+ non-effector lymphocytes is increased in COPD—modulating effects of moxifloxacin and dexamethasone
…, J Knobloch, Y Yakin, D Jungck, K Urban… - International …, 2011 - Elsevier
T-lymphocytes are crucial in chronic obstructive pulmonary disease (COPD) pathogenesis.
Especially T H 1-lymphocytes are involved in local and systemic inflammation in COPD, yet …
Especially T H 1-lymphocytes are involved in local and systemic inflammation in COPD, yet …
Intramyocardially transplanted neonatal cardiomyocytes (NCMs) show structural and electrophysiological maturation and integration and dose-dependently stabilize …
…, S Eschrig, T Kaluschke, K Urban… - Cell …, 2017 - journals.sagepub.com
Cardiac cell replacement therapy is a promising therapy to improve cardiac function in heart
failure. Persistence, structural and functional maturation, and integration of transplanted …
failure. Persistence, structural and functional maturation, and integration of transplanted …
Effects Of RV1088, A Narrow Spectrum Kinase Inhibitor, On Pro-Inflammatory Cytokine Production In Smooth Muscle Cells Obtained From COPD Patients
J Knobloch, K Urban, D Jungck, E Stoelben… - … IN ASTHMA AND …, 2011 - atsjournals.org
METHODS Six moderate to severe COPD patients were recruited, airway smooth muscle cells
were separated from lung tissue removed surgically and maintained in culture. Cells were …
were separated from lung tissue removed surgically and maintained in culture. Cells were …