The essential medicinal chemistry of curcumin: miniperspective
Curcumin is a constituent (up to ∼5%) of the traditional medicine known as turmeric. Interest
in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led …
in the therapeutic use of turmeric and the relative ease of isolation of curcuminoids has led …
The essential medicinal chemistry of cannabidiol (CBD)
This Perspective of the published essential medicinal chemistry of cannabidiol (CBD)
provides evidence that the popularization of CBD-fortified or CBD-labeled health products and …
provides evidence that the popularization of CBD-fortified or CBD-labeled health products and …
[HTML][HTML] Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors
JL Dahlin, KM Nelson, JM Strasser… - Nature …, 2017 - nature.com
Many compounds with potentially reactive chemical motifs and poor physicochemical properties
are published as selective modulators of biomolecules without sufficient validation and …
are published as selective modulators of biomolecules without sufficient validation and …
[PDF][PDF] Engineering the substrate specificity of the DhbE adenylation domain by yeast cell surface display
K Zhang, KM Nelson, K Bhuripanyo, KD Grimes… - Chemistry & Biology, 2013 - cell.com
The adenylation (A) domains of nonribosomal peptide synthetases (NRPSs) activate aryl
acids or amino acids to launch their transfer through the NRPS assembly line for the …
acids or amino acids to launch their transfer through the NRPS assembly line for the …
Adenylating enzymes in Mycobacterium tuberculosis as drug targets
BP Duckworth, KM Nelson… - Current topics in …, 2012 - ingentaconnect.com
Adenylation or adenylate-forming enzymes (AEs) are widely found in nature and are responsible
for the activation of carboxylic acids to intermediate acyladenylates, which are mixed …
for the activation of carboxylic acids to intermediate acyladenylates, which are mixed …
Development of a Selective Activity-Based Probe for Adenylating Enzymes: Profiling MbtA Involved in Siderophore Biosynthesis from Mycobacterium tuberculosis
BP Duckworth, DJ Wilson, KM Nelson… - ACS chemical …, 2012 - ACS Publications
MbtA is an adenylating enzyme from Mycobacterium tuberculosis that catalyzes the first step
in the biosynthesis of the mycobactins. A bisubstrate inhibitor of MbtA (Sal-AMS) was …
in the biosynthesis of the mycobactins. A bisubstrate inhibitor of MbtA (Sal-AMS) was …
[HTML][HTML] Ultrasensitive detection of salivary SARS-CoV-2 IgG antibodies in individuals with natural and COVID-19 vaccine-induced immunity
We assessed the feasibility of a highly sensitive immunoassay method based on single
molecule array (Simoa) technology to detect IgG and IgA antibodies against SARS-CoV-2 spike …
molecule array (Simoa) technology to detect IgG and IgA antibodies against SARS-CoV-2 spike …
[HTML][HTML] Curcumin may (not) defy science
We wrote “The Essential Medicinal Chemistry of Curcumin”(TEMCC) 1 to raise awareness
among medicinal chemists, natural product chemists, and other scientists to the challenges …
among medicinal chemists, natural product chemists, and other scientists to the challenges …
[HTML][HTML] A soluble truncated tau species related to cognitive dysfunction is elevated in the brain of cognitively impaired human individuals
…, LJ Kemper, K Leinonen-Wright, KM Nelson… - Scientific reports, 2020 - nature.com
Neurofibrillary tangles are a pathological hallmark of Alzheimer’s disease, and their levels
correlate with the severity of cognitive dysfunction in humans. However, experimental …
correlate with the severity of cognitive dysfunction in humans. However, experimental …
Immunogenicity and efficacy of baculovirus-expressed and DNA-based equine influenza virus hemagglutinin vaccines in mice
…, N Dybdahl-Sissoko, BR Schram, KM Nelson… - Vaccine, 1997 - Elsevier
Two fundamentally different approaches to vaccination of BALB/c mice with the hemagglutinin
(HA) of A/Equine/Kentucky/1/81 (H3N8) (Eq/KY) were evaluated, that is, administration of …
(HA) of A/Equine/Kentucky/1/81 (H3N8) (Eq/KY) were evaluated, that is, administration of …