Inhibition of nitric oxide synthase attenuates blood-brain barrier disruption during experimental meningitis

KMK Boje - Brain research, 1996 - Elsevier
Increased permeability of the blood-brain (BB) barrier is observed during meningitis.
Preventing BB barrier alterations is important because adverse neurological outcomes are …

GHB (γ-hydroxybutyrate) carrier-mediated transport across the blood-brain barrier

I Bhattacharya, KMK Boje - Journal of Pharmacology and Experimental …, 2004 - ASPET
γ-Hydroxybutyrate (sodium oxybate, GHB) is an approved therapeutic agent for cataplexy
with narcolepsy. GHB is widely abused as an anabolic agent, euphoriant, and date rape drug. …

Nitric oxide and prostaglandin E2 formation parallels blood–brain barrier disruption in an experimental rat model of bacterial meningitis

…, PJ Korytko, SS Lakhman, KMK Boje - Brain research …, 1998 - Elsevier
During meningitis, the host produces a plethora of signaling agents as part of a coordinated
defense mechanism against invading pathogens. Nitric oxide (NO) and prostaglandin E 2 (…

Consideration of aggressive and strategic approaches to address declining enrollment in US pharmacy schools

N Pavuluri, RR Aparasu, KMK Boje, J Danielson… - American Journal of …, 2019 - Elsevier
Members from Cohort 13 of the Academic Leadership Fellows Program (ALFP) 2016-2017
were challenged to present a debate on the topic: “In Turbulent Times, Pharmacy Education …

Nitric oxide redox species exert differential permeability effects on the blood-brain barrier

KMK Boje, SS Lakhman - Journal of Pharmacology and Experimental …, 2000 - ASPET
Excessive production of nitric oxide (NO) in the central nervous system is suspected to
contribute to neurodegenerative diseases. Previous studies showed that excessive central …

Pharmacokinetics and pharmacodynamics of γ-hydroxybutyric acid during tolerance in rats: Effects on extracellular dopamine

JJ Raybon, KMK Boje - Journal of Pharmacology and Experimental …, 2007 - ASPET
γ-Hydroxybutyrate (GHB) is a potent sedative/hypnotic and drug of abuse. Tolerance
develops to GHB's sedative/hypnotic effects. It is hypothesized that GHB tolerance may be …

Neuroinflammatory role of prostaglandins during experimental meningitis: evidence suggestive of an in vivo relationship between nitric oxide and prostaglandins

KMK Boje, D Jaworowicz, JJ Raybon - Journal of Pharmacology and …, 2003 - ASPET
Nitric oxide (NO) and prostaglandins are inflammatory mediators produced during meningitis.
The purpose of the present study was to pharmacologically inhibit cyclooxygenase-2 (COX…

Potential γ-hydroxybutyric acid (GHB) drug interactions through blood–brain barrier transport inhibition: a pharmacokinetic simulation-based evaluation

I Bhattacharya, KMK Boje - Journal of pharmacokinetics and …, 2006 - Springer
Recreational abuse or overdose of γ-hydroxybutyric acid (GHB) results in dose-dependent
central nervous system (CNS) effects including death. As GHB undergoes monocarboxylic …

Chronic administration of NMDA glycine partial agonists induces tolerance in the Porsolt swim test

T Lopes, P Neubauer, KMK Boje - Pharmacology Biochemistry and …, 1997 - Elsevier
The Porsolt swim test (PST) was used to assess behavioral effects following acute or
chronic treatment with two N-methyl-d-aspartate (NMDA) glycine partial agonists, 1-…

Blood–brain barrier transport studies of organic guanidino cations using an in situ brain perfusion technique

KMM Doan, SS Lakhman, KMK Boje - Brain research, 2000 - Elsevier
Blood–brain barrier (BBB) transport of essential polar substrates is mediated by specific,
carrier-mediated transport proteins. The BBB transport mechanisms for polar compounds with …