The liver is an attractive target tissue for gene therapy. Current approaches for hepatic gene
delivery include retroviral and adenoviral vectors, liposome/DNA, and peptide/DNA …

Regulation of cellular metabolism by the citric acid cycle occurs in the mitochondria. However,
the citric acid cycle intermediate succinate was shown recently to be a ligand for the G-…

Lymphocyte trafficking out of secondary lymphoid organs is regulated by concentration
gradient–dependent interactions between the membrane-derived lysophospholipid signaling …

The critical physiological functions of the liver make hepatocytes important targets for therapeutic
gene delivery. This study reports significant gene expression following direct injection …

Objective Etrasimod (APD334) is a next‐generation oral sphingosine‐1‐phosphate (S1P)
modulator with an optimized S1P receptor activity profile currently in Phase 2 clinical trials for …

Vascular endothelial growth factor was infused into rat carotid arteries for 3 minutes immediately
after endothelial denudation by balloon injury. Endothelial proliferation was determined …

The cytomegalovirus (CMV) major immediate-early promoter/enhancer is active in many
cell culture systems and is considered to be one of the strongest promoters in vitro. However, …

As described in chapter 1, our group has developed a gene delivery system called D-RECS
(Drug-or Gene-delivery systems responding to cellular signals). Based on this strategy, we …

Inflammatory bowel disease (IBD) is chronic inflammation of the gastrointestinal tract that has
a high epidemiological prevalence worldwide. The increasing disease burden worldwide, …

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reproduced from the microfilm master. UMl films the text directly from the original or copy …