Constitutive activity of G-protein-coupled receptors: cause of disease and common property of wild-type receptors
R Seifert, K Wenzel-Seifert - Naunyn-Schmiedeberg's archives of …, 2002 - Springer
The aim of this review is to provide a systematic overview on constitutively active G-protein-coupled
receptors (GPCRs), a rapidly evolving area in signal transduction research. We will …
receptors (GPCRs), a rapidly evolving area in signal transduction research. We will …
[HTML][HTML] QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes
K Wenzel-Seifert, M Wittmann… - Deutsches Ärzteblatt …, 2011 - ncbi.nlm.nih.gov
… Wenzel-Seifert states that she has no conflict of interest. … Wenzel-Seifert K, Wittmann M,
Haen E. Torsade de Pointes episodes under treatment with selective serotonin reuptake inhibitors…
Haen E. Torsade de Pointes episodes under treatment with selective serotonin reuptake inhibitors…
Molecular analysis of β2-adrenoceptor coupling to Gs-, Gi-, and Gq-proteins
K Wenzel-Seifert, R Seifert - Molecular pharmacology, 2000 - ASPET
The β 2 -adrenoceptor (β 2 AR) couples to the G-protein G s to activate adenylyl cyclase.
Intriguingly, several studies have demonstrated that the β 2 AR can also interact with G-proteins …
Intriguingly, several studies have demonstrated that the β 2 AR can also interact with G-proteins …
Cyclosporin H is a potent and selective formyl peptide receptor antagonist. Comparison with Nt-butoxycarbonyl-L-phenylalanyl-L-leucyl-L-phenylalanyl-L-leucyl-L …
K Wenzel-Seifert, R Seifert - Journal of immunology (Baltimore, Md …, 1993 - journals.aai.org
The cyclic undecapeptide, cyclosporin (Cs) H, is a potent inhibitor of FMLP-induced superoxide
anion (O2-) formation in human neutrophils. We studied the effects of CsH in comparison …
anion (O2-) formation in human neutrophils. We studied the effects of CsH in comparison …
Functional differences between full and partial agonists: evidence for ligand-specific receptor conformations
R Seifert, K Wenzel-Seifert, U Gether… - Journal of Pharmacology …, 2001 - ASPET
The interaction of an agonist-bound G-protein-coupled receptor (GPCR) with its cognate G-protein
initiates a sequence of experimentally quantifiable changes in both the GPCR and G-…
initiates a sequence of experimentally quantifiable changes in both the GPCR and G-…
GPCR–Gα fusion proteins: molecular analysis of receptor–G-protein coupling
R Seifert, K Wenzel-Seifert, BK Kobilka - Trends in pharmacological …, 1999 - cell.com
The efficiency of interactions between G-protein-coupled receptors (GPCRs) and heterotrimeric
guanine nucleotide-binding proteins (G proteins) is greatly influenced by the absolute …
guanine nucleotide-binding proteins (G proteins) is greatly influenced by the absolute …
[HTML][HTML] Different effects of Gsα splice variants on β2-adrenoreceptor-mediated signaling: the β2-adrenoreceptor coupled to the long splice variant of Gsα has …
R Seifert, K Wenzel-Seifert, TW Lee, U Gether… - Journal of Biological …, 1998 - ASBMB
The β 2 -adrenoreceptor (β 2 AR) couples to the G-protein G s to mediate adenylyl cyclase
activation. The splice variants of G s α differ by a 15-amino acid insert between the Ras-like …
activation. The splice variants of G s α differ by a 15-amino acid insert between the Ras-like …
Effects of guanine, inosine, and xanthine nucleotides on β2-adrenergic receptor/Gs interactions: evidence for multiple receptor conformations
R Seifert, U Gether, K Wenzel-Seifert, BK Kobilka - Molecular Pharmacology, 1999 - ASPET
The aim of our study was to examine the effects of different purine nucleotides [GTP, ITP, and
xanthosine 5′-triphosphate (XTP)] on receptor/G protein coupling. As a model system, we …
xanthosine 5′-triphosphate (XTP)] on receptor/G protein coupling. As a model system, we …
Multiple differences in agonist and antagonist pharmacology between human and guinea pig histamine H1-receptor
R Seifert, K Wenzel-Seifert, T Bürckstümmer… - … of Pharmacology and …, 2003 - ASPET
… We also calculated the ratio of the K B values for hH 1 R and gpH 1 R (Pot. Rat. gpH 1 R/hH …
We also calculated the ratio of the K i values for hH 1 R and gpH 1 R (Aff. Rat. gp/h) and the …
We also calculated the ratio of the K i values for hH 1 R and gpH 1 R (Aff. Rat. gp/h) and the …
[HTML][HTML] G-protein-coupled receptors in HL-60 human leukemia cells
JF Klinker, K Wenzel-Seifert, R Seifert - General Pharmacology: The …, 1996 - Elsevier
1. HL-60 human leukemia cells are a widely employed model system for the analysis of
signal transduction processes mediated via regulatory heterotrimeric guanine nucleotide-…
signal transduction processes mediated via regulatory heterotrimeric guanine nucleotide-…