User profiles for K. Nahmod
Karen A Nahmod, MD PhDHematopathology Fellow. MD Anderson Cancer Center Verified email at mdanderson.org Cited by 1904 |
Early-onset lymphoproliferation and autoimmunity caused by germline STAT3 gain-of-function mutations
…, KL McClain, LB Karam, K Nahmod… - Blood, The Journal …, 2015 - ashpublications.org
Germline loss-of-function mutations in the transcription factor signal transducer and
activator of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function …
activator of transcription 3 (STAT3) cause immunodeficiency, whereas somatic gain-of-function …
COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis
Unbiased genetic studies have uncovered surprising molecular mechanisms in human
cellular immunity and autoimmunity 1 . We performed whole-exome sequencing and targeted …
cellular immunity and autoimmunity 1 . We performed whole-exome sequencing and targeted …
Interplay of pathogens, cytokines and other stress signals in the regulation of dendritic cell function
Dendritic cells (DCs) are the only antigen-presenting cell capable of activating naïve T
lymphocytes, and hence they play a crucial role in the induction of adaptive immunity. Immature …
lymphocytes, and hence they play a crucial role in the induction of adaptive immunity. Immature …
Control of dendritic cell differentiation by angiotensin II
KA Nahmod, ME Vermeulen, S Radien… - The FASEB …, 2003 - Wiley Online Library
Here we analyze the role of the angiotensinergic system in the differentiation of dendritic cells
(DC). We found that human monocytes produce angiotensin II (AII) and express AT1 and …
(DC). We found that human monocytes produce angiotensin II (AII) and express AT1 and …
STAT3 inhibition prevents lung inflammation, remodeling, and accumulation of Th2 and Th17 cells in a murine asthma model
AC Gavino, K Nahmod, U Bharadwaj, G Makedonas… - Allergy, 2016 - Wiley Online Library
Background STAT 3 drives development of Th17 cells and cytokine production by Th2 and
Th17 cells, which contribute to asthma. Alternative asthma treatments are needed, especially …
Th17 cells, which contribute to asthma. Alternative asthma treatments are needed, especially …
Extracellular acidosis triggers the maturation of human dendritic cells and the production of IL-12
Although the development of an acidic tissue environment or acidosis is a hallmark of
inflammatory processes, few studies analyze the effect of extracellular pH on immune cells. We …
inflammatory processes, few studies analyze the effect of extracellular pH on immune cells. We …
New insights into the mechanisms controlling neutrophil survival
M Cabrini, K Nahmod, J Geffner - Current opinion in hematology, 2010 - journals.lww.com
The control of neutrophil survival is central to homoeostasis and resolution of inflammation.
Cell death is usually discussed dichotomously in terms of apoptosis or necrosis. There are …
Cell death is usually discussed dichotomously in terms of apoptosis or necrosis. There are …
Nonpeptide antagonists of AT1 receptor for angiotensin II delay the onset of acute respiratory distress syndrome
S Raiden, K Nahmod, V Nahmod, G Semeniuk… - … of Pharmacology and …, 2002 - ASPET
We have previously reported that losartan, a selective antagonist of AT1 receptors for
angiotensin II (AII), strongly suppresses the activation of neutrophils byN-formylmethionyl-leucyl-…
angiotensin II (AII), strongly suppresses the activation of neutrophils byN-formylmethionyl-leucyl-…
Human Seminal Plasma Abrogates the Capture and Transmission of Human Immunodeficiency Virus Type 1 to CD4+ T Cells Mediated by DC-SIGN
…, S Raiden, M Vermeulen, K Nahmod… - Journal of …, 2007 - Am Soc Microbiol
Dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin (DC-SIGN) is
expressed by dendritic cells (DCs) at mucosal surfaces and appears to play an important …
expressed by dendritic cells (DCs) at mucosal surfaces and appears to play an important …
From the archives of MD Anderson cancer center: Aleukemic T-prolymphocytic leukemia, a rare presentation and review of the literature
T-prolymphocytic leukemia (T-PLL) is a rare, aggressive T-cell leukemia, and patients typically
present with marked peripheral blood lymphocytosis. Approximately 15–20 % of patients …
present with marked peripheral blood lymphocytosis. Approximately 15–20 % of patients …