Animal models of human diseases that accurately recapitulate clinical pathology are
indispensable for understanding molecular mechanisms and advancing preclinical studies. The …

The endoplasmic reticulum (ER) uses an elaborate surveillance system called the ER quality
control (ERQC) system. The ERQC facilitates folding and modification of secretory and …

… is relatively low for molecular interactions and can be accounted for by the rapid dissociation
rate constant (K d > 10-2s -1) and considerably high association rate constant (K a~2• …

Indirect immunofluorescence of certain human sera demonstrated an antigen(s) in the cytoplasm
of 1--5% of the cells of a T-cell line, MT-1, from a patient with adult T-cell leukemia (ATL)…

Rac is a small GTPase of the Rho family that mediates stimulus-induced actin cytoskeletal
reorganization to generate lamellipodia 1 , 2 , 3 , 4 , 5 . Little is known about the signalling …

… Both lines exhibited specific binding of 3 H-PGD 2 with similar numbers of binding sites
per cell and K d values of 31.3 and 37.7 nM, respectively, whereas 3 H-PGD 2 did not bind to …

Unfolded and malfolded client proteins impose a stress on the endoplasmic reticulum (ER),
which contributes to cell death in pathophysiological conditions. The transcription factor C/…

A recent nationwide survey of the lymphocyte subpopulations of leukaemia and lymphoma in
Japan has disclosed a high incidence of adult T-cell leukaemia (ATL) 1 . One of the striking …

… As shown in Figure 3K, the efficiency in mediating syncytia formation of BA.2 S was … S in
293-ACE2/TMPRSS2 cells was comparable (Figure 3K). These results suggest that the relatively …

… saccharide modification in the early secretory pathway directs the Mori, K. (2001b). … ing
transcription factors 6ɑ and 6ß that activates the mammalian Mori, K. (2000). Tripartite …