Prostaglandins (PGs) such as PGE 2 enhance proliferation in many cells, apparently through
several distinct mechanisms, including transactivation of the epidermal growth factor (EGF) …

Prostaglandins stimulate hepatocyte proliferation in vivo and in vitro. We have examined the
role of E prostanoid (EP) and F prostanoid receptors (FP) in enhancing the growth-…

Background: It is important to understand the mechanisms by which the cells integrate
signals from different receptors. Several lines of evidence implicate epidermal growth factor (EGF) …

Background It is important to understand the mechanisms by which the cells integrate
signals from different receptors. Several lines of evidence implicate epidermal growth factor (EGF) …

The prostaglandin E 2 (PGE 2 ) G protein-coupled receptor (GPCR), EP2, plays important
roles in mouse skin tumor development (Chun, KS, Lao, HC, Trempus, CS, Okada, M., and …

Activated microglia produce a factor or cocktail of factors that promotes cholinergic neuronal
differentiation of undifferentiated precursors in the embryonic basal forebrain (BF) in vitro. …

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risks for
esophageal, gastric and colon cancers as well as other solid tumors. The antitumor effect of …

Cyclooxygenase-2 (COX-2), the key enzyme of the conversion of arachidonic acid to
prostaglandins is an important regulator of inflammation and perhaps apoptosis. Genistein is an …

Prostaglandin E 2 (PGE 2 ) enhances the mitogenic response to epidermal growth factor (EGF)
in hepatocytes, but the underlying mechanisms are not clear. We previously observed …