Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity
L Liu, TP Wong, MF Pozza, K Lingenhoehl, Y Wang… - Science, 2004 - science.org
Activation of N-methyl-d-aspartate subtype glutamate receptors (NMDARs) is required for
long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic …
long-term potentiation (LTP) and long-term depression (LTD) of excitatory synaptic …
Positive allosteric modulation of native and recombinant γ-aminobutyric acidB receptors by 2, 6-di-tert-butyl-4-(3-hydroxy-2, 2-dimethyl-propyl)-phenol (CGP7930) and …
…, J Mosbacher, K Lingenhoehl, J Heid, K Hofstetter… - Molecular …, 2001 - ASPET
The compounds CGP7930 [2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol] and
its close analog CGP13501 were identified as positive modulators of γ-aminobutyric acid B (…
its close analog CGP13501 were identified as positive modulators of γ-aminobutyric acid B (…
Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N, N′-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4, 6-diamine) …
…, C Gentsch, C Mombereau, K Lingenhoehl… - … of Pharmacology and …, 2004 - ASPET
The role of GABA B receptors in various behavioral processes has been largely defined using
the prototypical GABA B receptor agonist baclofen. However, baclofen induces sedation, …
the prototypical GABA B receptor agonist baclofen. However, baclofen induces sedation, …
5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition
…, H Allgeier, S Bischoff, K Lingenhoehl… - Bioorganic & medicinal …, 2002 - Elsevier
NMDA antagonists derived from 5-phosphonomethyl-1,4-dihydroquinoxaline-2,3-dione (3a)
are potent anticonvulsant agents, and display strong protective effects in the electroshock-…
are potent anticonvulsant agents, and display strong protective effects in the electroshock-…
N, N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4, 6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of γ-aminobutyric …
S Urwyler, MF Pozza, K Lingenhoehl… - … of Pharmacology and …, 2003 - ASPET
… In fact, saturation experiments with the antagonist radioligand [ 3 H]CGP62349 revealed a
slight increase in the K d value (0.54 nM in the absence and 0.92 nM in the presence of 30 μM …
slight increase in the K d value (0.54 nM in the absence and 0.92 nM in the presence of 30 μM …
Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function: I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain
…, A Pagano, PJ Flor, I Vranesic, K Lingenhoehl… - …, 2001 - Elsevier
The excitatory neurotransmitter, glutamate, is particularly important in the transmission of
pain information in the nervous system through the activation of ionotropic and metabotropic …
pain information in the nervous system through the activation of ionotropic and metabotropic …
γ-Hydroxybutyrate is a weak agonist at recombinant GABAB receptors
K Lingenhoehl, R Brom, J Heid, P Beck, W Froestl… - …, 1999 - Elsevier
… Therefore, we calculated the dissociation constants K i for CGP54626A and CGP35348
from binding experiments on recombinant GABA B R1/R2 and from our functional experiments. …
from binding experiments on recombinant GABA B R1/R2 and from our functional experiments. …
The selective nicotinic acetylcholine receptor α7 agonist JN403 is active in animal models of cognition, sensory gating, epilepsy and pain
D Feuerbach, K Lingenhoehl, HR Olpe, A Vassout… - …, 2009 - Elsevier
Several lines of evidence suggest that the nicotinic acetylcholine receptor α7 (nAChR α7) is
involved in central nervous system disorders like schizophrenia and Alzheimer's disease as …
involved in central nervous system disorders like schizophrenia and Alzheimer's disease as …
The anticonvulsant gabapentin (Neurontin) does not act through γ-aminobutyric acid-B receptors
AA Jensen, J Mosbacher, S Elg, K Lingenhoehl… - Molecular …, 2002 - ASPET
The actions of the anticonvulsant gabapentin [1-(aminomethyl)cyclohexaneacetic acid,
Neurontin] have been somewhat enigmatic until recently, when it was claimed to be a γ-…
Neurontin] have been somewhat enigmatic until recently, when it was claimed to be a γ-…
Electrophysiological studies on the hippocampus and prefrontal cortex assessing the effects of amyloidosis in amyloid precursor protein 23 transgenic mice
S Roder, L Danober, MF Pozza, K Lingenhoehl… - Neuroscience, 2003 - Elsevier
In vitro and in vivo electrophysiological studies were done to investigate the neuronal
function of the hippocampus and prefrontal cortex in the amyloid precursor protein (APP) 23 …
function of the hippocampus and prefrontal cortex in the amyloid precursor protein (APP) 23 …