User profiles for K. Inyang

Kufreobong Inyang

Postdoctoral Research Associate, Michigan State University
Verified email at cornell.edu
Cited by 413

Commonalities between pain and memory mechanisms and their meaning for understanding chronic pain

TJ Price, KE Inyang - Progress in molecular biology and translational …, 2015 - Elsevier
Pain sensing neurons in the periphery (called nociceptors) and the central neurons that
receive their projections show remarkable plasticity following injury. This plasticity results in …

The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice

KE Inyang, T Szabo-Pardi, E Wentworth… - Pharmacological …, 2019 - Elsevier
Metformin is a widely prescribed drug used in the treatment of type II diabetes. While the drug
has many mechanisms of action, most of these converge on AMP activated protein kinase (…

Interleukin-10 signaling in somatosensory neurons controls CCL2 release and inflammatory response

…, J Sim, KE Inyang, A Dagenais, K Monahan… - Brain, Behavior, and …, 2023 - Elsevier
Appropriate regulation of the inflammatory response is essential for survival. Interleukin-10 (IL-10),
a well-known anti-inflammatory cytokine, plays a major role in controlling inflammation…

HPV+ head and neck cancer–derived small extracellular vesicles communicate with TRPV1+ neurons to mediate cancer pain

KE Inyang, CM Evans, M Heussner, M Petroff… - Pain, 2024 - journals.lww.com
Severe pain is often experienced by patients with head and neck cancer and is associated
with a poor prognosis. Despite its frequency and severity, current treatments fail to adequately …

[HTML][HTML] Alleviation of paclitaxel-induced mechanical hypersensitivity and hyperalgesic priming with AMPK activators in male and female mice

KE Inyang, TA McDougal, ED Ramirez, M Williams… - Neurobiology of Pain, 2019 - Elsevier
AMP-activated protein kinase (AMPK) is an energy-sensing kinase that has emerged as a
novel therapeutic target for pain due to its ability to inhibit mechanistic target of rapamycin (…

Can FDA-approved immunomodulatory drugs be repurposed/repositioned to alleviate chronic pain?

KE Inyang, JK Folger, G Laumet - Journal of Neuroimmune Pharmacology, 2021 - Springer
Pain is among the most widespread chronic health condition confronting society today and
our inability to manage chronic pain contributes to the opioid abuse epidemic in America. The …

Pharmacological activation of AMPK inhibits incision-evoked mechanical hypersensitivity and the development of hyperalgesic priming in mice

…, DV Tillu, K Mazhar, GL Mejia, MN Asiedu, K Inyang… - Neuroscience, 2017 - Elsevier
New therapeutics to manage post-surgical pain are needed to mitigate the liabilities of
opioid and other analgesics. Our previous work shows that key modulators of excitability in …

Indirect AMP-activated protein kinase activators prevent incision-induced hyperalgesia and block hyperalgesic priming, whereas positive allosteric modulators block …

KE Inyang, MD Burton, T Szabo-Pardi… - … of Pharmacology and …, 2019 - ASPET
AMP-activated protein kinase (AMPK) is a multifunctional kinase that negatively regulates
the mechanistic target of rapamycin (mTOR) and mitogen-activated protein kinase (MAPK) …

A peptidomimetic modulator of the CaV2.2 N-type calcium channel for chronic pain

…, D Giuvelis, W Zuo, KE Inyang… - Proceedings of the …, 2023 - National Acad Sciences
… We recently used this approach to discover a small molecule neuroprotectant that interferes
with K v 2.1 binding to syntaxin1a (53). Here, using this pipeline, we identified the anchor …

The µ-δ opioid heteromer masks latent pain sensitization in neuropathic and inflammatory pain in male and female mice

KE Inyang, SR George, G Laumet - Brain Research, 2021 - Elsevier
The episodic nature of chronic pain can be studied in the rodent model of latent pain
sensitization. After remission, central sensitization is opposed by activation of opioid receptors. At …