… Zuideveld, Jan Fagerberg Collection and assembly of data: Laurent Claret, Paulo M. Hoff,
Klaas P. … Zuideveld, Karin Jorga, Jan Fagerberg, René Bruno Manuscript writing: Laurent …

Background. A randomized, double-blind study was conducted to evaluate the
pharmacokinetics of ganciclovir following oral administration of ganciclovir or valganciclovir for …

Aims Allometric equations have proven useful for the extrapolation of animal data to determine
pharmacokinetic parameters in man. It has been proposed that these equations are also …

Aims It is well established that there is a wide intra‐ and interindividual variability in dose
requirements for lorazepam and midazolam in intensive care patients. The objective of this …

For the purpose of developing a longitudinal model to predict hand‐and‐foot syndrome (HFS)
dynamics in patients receiving capecitabine, data from two large phase III studies were …

Background: The objective is to study the population pharmacokinetics of lorazepam and
midazolam in critically ill patients with acute renal failure who are treated with continuous …

Objectives A population pharmacokinetic and pharmacodynamic model of propofol for long‐term
sedation in critically ill patients is described, because limited information is available in …

Insulin-like growth factor I (IGF-I) is a growth-promoting anabolic hormone that fosters cell
growth and tissue homeostasis. IGF-I deficiency is associated with several diseases, including …

Purpose The aim of the present study was to assess whether two widely used biomarkers for
5-HT 1A -receptor mediated responses in the rat (hypothermia and corticosterone increase) …

Objective The objective of the present investigation was to develop a population pharmacodynamic
model for midazolam- and lorazepam-induced sedation upon long-term continuous …