Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes
S Mei, HM Ni, S Manley, A Bockus, KM Kassel… - … of Pharmacology and …, 2011 - ASPET
Fatty acid-induced lipotoxicity plays a critical role in the pathogenesis of nonalcoholic liver
disease. Saturated fatty acids and unsaturated fatty acids have differential effects on cell …
disease. Saturated fatty acids and unsaturated fatty acids have differential effects on cell …
Hepatocyte tissue factor activates the coagulation cascade in mice
…, JA Brown, SC Bishop, KM Kassel… - Blood, The Journal …, 2013 - ashpublications.org
In this study, we characterized tissue factor (TF) expression in mouse hepatocytes (HPCs)
and evaluated its role in mouse models of HPC transplantation and acetaminophen (APAP) …
and evaluated its role in mouse models of HPC transplantation and acetaminophen (APAP) …
Inhibition of human airway smooth muscle cell proliferation by β2-adrenergic receptors and cAMP is PKA independent: evidence for EPAC involvement
KM Kassel, TA Wyatt… - American Journal of …, 2008 - journals.physiology.org
Mechanisms by which β-adrenergic receptor (βAR) agonists inhibit proliferation of human
airway smooth muscle (HASM) cells were investigated because of their potential relevance to …
airway smooth muscle (HASM) cells were investigated because of their potential relevance to …
Thrombin Inhibition with Dabigatran Protects against High-Fat Diet–Induced Fatty Liver Disease in Mice
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and metabolic
syndrome. Robust coagulation cascade activation is common in obese patients with …
syndrome. Robust coagulation cascade activation is common in obese patients with …
[HTML][HTML] Protease-activated receptor 1 and hematopoietic cell tissue factor are required for hepatic steatosis in mice fed a Western diet
KM Kassel, AP Owens III, CE Rockwell… - The American journal of …, 2011 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of obesity and
metabolic syndrome and contributes to increased risk of cardiovascular disease and liver-related …
metabolic syndrome and contributes to increased risk of cardiovascular disease and liver-related …
Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice
Farnesoid X receptor (FXR, Nr1h4) and small heterodimer partner (SHP, Nr0b2) are nuclear
receptors that are critical to liver homeostasis. Induction of SHP serves as a major …
receptors that are critical to liver homeostasis. Induction of SHP serves as a major …
[HTML][HTML] Regulation of human cytidine triphosphate synthetase 2 by phosphorylation
KM Kassel, MJ Higgins, M Hines, LM Graves - Journal of biological …, 2010 - ASBMB
… Kinetic analysis demonstrated that both hCTPS1 and hCTPS2 were maximally active at
physiological concentrations of ATP, GTP, and glutamine, whereas the Km and IC 50 values for …
physiological concentrations of ATP, GTP, and glutamine, whereas the Km and IC 50 values for …
[HTML][HTML] Therapeutic administration of the direct thrombin inhibitor argatroban reduces hepatic inflammation in mice with established fatty liver disease
KM Kassel, BP Sullivan, W Cui, BL Copple… - The American journal of …, 2012 - Elsevier
Thrombin generation is increased in patients with nonalcoholic fatty liver disease (NAFLD)
and in mouse models of diet-induced obesity. Deficiency in the thrombin receptor protease …
and in mouse models of diet-induced obesity. Deficiency in the thrombin receptor protease …
[HTML][HTML] Monocyte chemoattractant protein-1 deficiency does not affect steatosis or inflammation in livers of mice fed a methionine–choline-deficient diet
Monocyte chemoattractant protein-1 (MCP-1, Ccl2) expression is increased in livers of patients
with nonalcoholic steatohepatitis and in murine models of steatohepatitis. Several studies …
with nonalcoholic steatohepatitis and in murine models of steatohepatitis. Several studies …
[HTML][HTML] Fibrin (ogen)-independent role of plasminogen activators in acetaminophen-induced liver injury
BP Sullivan, KM Kassel, A Jone, MJ Flick… - The American journal of …, 2012 - Elsevier
Hepatic fibrin(ogen) has been noted to occur after acetaminophen (APAP)-induced liver injury
in mice. Deficiency in plasminogen activator inhibitor-1 (PAI-1), an endogenous inhibitor …
in mice. Deficiency in plasminogen activator inhibitor-1 (PAI-1), an endogenous inhibitor …