Cell migration and invasion are processes that offer rich targets for intervention in key
physiologic and pathologic phenomena such as wound healing and cancer metastasis. With the …

Rapid identification of both species and even specific strains of human pathogenic bacteria
grown on standard agar has been achieved from the volatiles they produce using a …

… Wylie P, Gehler S, Hulkower K: A novel multiplexed-compatible high throughput cell
migration screening assay using an Acumen eX3. Paper presented at the annual meeting of the …

Objective. In order to investigate potential regulatory mechanisms for the increased production
of prostaglandin E 2 (PGE 2 ) in interleukin‐1β (IL‐1β)–stimulated rheumatoid synovial …

Cathepsin B and in particular cell‐surface and secreted cathepsin B has been implicated in
the invasive and metastatic phenotype of numerous types of cancer. We describe here a …

Dual specificity mitogen-activated protein kinase (MAPK) phosphatases [dual specificity
phosphatase/MAP kinase phosphatase (DUSP-MKP)] have been hypothesized to maintain …

The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted
thiazoles to obtain a series of potent, selective inhibitors of COX-2. Additional substitutions …

Clostridium perfringens type A enterotoxin (CPE) is a membrane-active cytotoxin. There are
a number of recognized early steps in CPE cytotoxicity including binding of CPE to a protein …

Representative nonsteroidal anti-inflammatory drug (NSAID) cyclooxygenase inhibitors such
as ibuprofen, naproxen, and indomethacin were used as orally bioavailable scaffolds to …

A novel series of heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids was studied as
leukotriene biosynthesis inhibitors. A hypothesis of structure−activity optimization by …