Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease

…, RS Jones, V Rodriguez-Cruz, KE Follman… - Pharmacological …, 2020 - ASPET
… Substrates and inhibitors of the MCT family members and their respective K m , K i , or IC
50 values, as identified from in vitro systems, are listed in Table 3. It should be noted that K m …

Treatment of γ-hydroxybutyric acid and γ-butyrolactone overdose with two potent monocarboxylate transporter 1 inhibitors, AZD3965 and AR-C155858

KE Follman, ME Morris - Journal of Pharmacology and Experimental …, 2019 - ASPET
The illicit use of γ-hydroxybutyric acid (GHB), and its prodrug, γ-butyrolactone (GBL), results
in severe adverse effects including sedation, coma, respiratory depression, and death. …

Factors influencing the self‐efficacy beliefs of first‐year engineering students

MA Hutchison, DK Follman, M Sumpter… - Journal of …, 2006 - Wiley Online Library
A survey incorporating qualitative measures of student self‐efficacy beliefs was administered
to 1,387 first‐year engineering students enrolled in ENGR 106, Engineering Problem‐…

[HTML][HTML] Integrated population pharmacokinetics of immunoglobulin G following intravenous or subcutaneous administration of various immunoglobulin products in …

Z Li, K Follman, E Freshwater, F Engler, L Yel - International …, 2022 - Elsevier
Plasma-derived immunoglobulin G (IgG) replacement therapy represents the current
standard of care for patients with primary or secondary antibody deficiencies, and includes …

Prediction of the effects of renal impairment on clearance for organic cation drugs that undergo renal secretion: a simulation-based study

KE Follman, ME Morris - Drug Metabolism and Disposition, 2018 - ASPET
Renal impairment (RI) is a major health concern with a growing prevalence. RI leads to
various physiologic changes, in addition to a decrease in glomerular filtration rate, that impact …

Factorial screening of antibody purification processes using three chromatography steps without protein A

DK Follman, RL Fahrner - Journal of chromatography A, 2004 - Elsevier
Protein A affinity chromatography is often employed as a capture step to meet the purity, yield,
and throughput requirements for pharmaceutical antibody purification. However, a trade-…

Providing a voice: Qualitative investigation of the impact of a first‐year engineering experience on students' efficacy beliefs

MA Hutchison‐Green, DK Follman… - Journal of Engineering …, 2008 - Wiley Online Library
This qualitative study explored the engineering self‐efficacy beliefs held by students enrolled
in their first engineering course at Purdue University. Findings from the thematic analysis of …

[HTML][HTML] Effects of Body Mass and Age on the Pharmacokinetics of Subcutaneous or Hyaluronidase-facilitated Subcutaneous Immunoglobulin G in Primary …

Z Li, K Follman, E Freshwater, F Engler… - Journal of Clinical …, 2023 - Springer
Purpose To assess the pharmacokinetics (PK) of subcutaneous immunoglobulin (SCIG)
and hyaluronidase-facilitated SCIG (fSCIG) therapy across body mass index (BMI) and age …

Effects of renal impairment on transporter‐mediated renal reabsorption of drugs and renal drug–drug interactions: A simulation‐based study

KE Follman, RA Dave, ME Morris - Biopharmaceutics & drug …, 2018 - Wiley Online Library
Renal impairment (RI) significantly impacts the clearance of drugs through changes in the
glomerular filtration rate, protein binding and alterations in the expression of renal drug …

Effect of chronic γ-hydroxybutyrate (GHB) administration on GHB toxicokinetics and GHB-induced respiratory depression

…, GS Chadha, MA Felmlee, KE Follman… - The American journal …, 2017 - Taylor & Francis
Background: γ-hydroxybutyrate (GHB) has a high potential for illicit use; overdose of this
compound results in sedation, respiratory depression and death. Tolerance to the hypnotic/…