Inflammatory cytokines in cystic fibrosis lungs.

…, MW Konstan, KA Hilliard, JB Hilliard… - American journal of …, 1995 - atsjournals.org
Chronic pulmonary infection with Pseudomonas aeruginosa continues to be the major cause
of morbidity and mortality in cystic fibrosis (CF). Several characteristics of CF, including the …

Bronchoalveolar lavage findings in cystic fibrosis patients with stable, clinically mild lung disease suggest ongoing infection and inflammation.

MW Konstan, KA Hilliard, TM Norvell… - American journal of …, 1994 - atsjournals.org
… Konstan MW, Walenga RW, Hilliard KA, Hilliard JB. leukotriene B4 markedly elevated in
the epithelial lining fluid of patients with cystic fibrosis. Am Rev Respir Dis 1993;148:896-901. …

Compacted DNA nanoparticles administered to the nasal mucosa of cystic fibrosis subjects are safe and demonstrate partial to complete cystic fibrosis transmembrane …

…, PB Davis, JS Wagener, KA Hilliard… - Human gene …, 2004 - liebertpub.com
A double-blind, dose escalation gene transfer trial was conducted in subjects with cystic fibrosis
(CF), among whom placebo (saline) or compacted DNA was superfused onto the inferior …

[HTML][HTML] A randomized double blind, placebo controlled phase 2 trial of BIIL 284 BS (an LTB4 receptor antagonist) for the treatment of lung disease in children and …

…, G Döring, SL Heltshe, LC Lands, KA Hilliard… - Journal of Cystic …, 2014 - Elsevier
Background Airway inflammation, mediated in part by LTB 4 , contributes to lung destruction
in patients with cystic fibrosis (CF). LTB 4 -receptor inhibition may reduce airway …

Leukotriene B~ 4 Markedly Elevated in the Epithelial Lining Fluid of Patients with Cystic Fibrosis

…, RW Walenga, KA Hilliard, JB Hilliard - American Review of …, 1993 - atsjournals.org
Persistent neutrophil infiltration into the airways of patients with cystic fibrosis (CF) results in
lung destruction. Eicosanoid lipid mediators, particularly leukotriene B4 (LTS4), may playa …

Effect of ibuprofen on neutrophil migration in vivo in cystic fibrosis and healthy subjects

…, MR Finney, HL Kirchner, KA Hilliard, JB Hilliard… - … of Pharmacology and …, 2003 - ASPET
Long-term treatment with ibuprofen twice daily, at doses that achieve peak plasma concentration
(C max ) >50 μg/ml, slows progression of lung disease in patients with cystic fibrosis (CF…

[HTML][HTML] 12/15-lipoxygenase activity promotes efficient inflammation resolution in a murine model of Lyme arthritis

CD Jackson, KA Hilliard, CR Brown - Frontiers in Immunology, 2023 - frontiersin.org
Infection of C3H/HeJ (C3H) mice with Borrelia burgdorferi results in the development of a
robust inflammatory arthritis that peaks around 3-4 weeks post-infection and then …

[HTML][HTML] Expansion of a novel population of NK cells with low ribosome expression in juvenile dermatomyositis

KA Hilliard, AA Throm, JT Pingel… - Frontiers in …, 2022 - frontiersin.org
Juvenile dermatomyositis (JDM) is a pediatric autoimmune disease associated with characteristic
rash and proximal muscle weakness. To gain insight into differential lymphocyte gene …

Use of nasal potential difference and sweat chloride as outcome measures in multicenter clinical trials in subjects with cystic fibrosis

…, ML Aitken, TJ Kelley, KA Hilliard… - Pediatric …, 2002 - Wiley Online Library
One of the goals of current research in cystic fibrosis (CF) is to develop treatments that
correct or compensate for defects in function of the cystic fibrosis transmembrane regulator (CFTR…

A phase I randomized, multicenter trial of CPX in adult subjects with mild cystic fibrosis

…, TJ Kelley, LJH Milgram, KA Hilliard… - Pediatric …, 2002 - Wiley Online Library
CPX (8‐cyclopentyl‐1,3‐dipropylxanthine) is a novel compound currently under development
as a potential treatment for cystic fibrosis (CF). The drug has been shown to increase …