Mutations in N-methyl-d-aspartate receptors (NMDAR) subunits have been implicated in a
growing number of human neurodevelopmental disorders. Previously, a de novo mutation in …

The neuronal cell death-promoting loss of cytoplasmic K + following injury is mediated by an
increase in Kv2.1 potassium channels in the plasma membrane. This phenomenon relies …

We present the design of an innovative molecular neuroprotective strategy and provide
proof-of-concept for its implementation, relying on the injury-mediated activation of an ectopic …

The neuron-specific K + /Cl − co-transporter-2, KCC2, which is critical for brain development,
regulates γ-aminobutyric acid-dependent inhibitory neurotransmission. Consistent with its …

… to 1 mM KA and 20 μM zinc in the presence of 250 nM pyrithione. Following overnight
incubation with KA and ZnPyr, coverslips were moved to fresh MHB before treatment with CuES. …

The photophysics of a covalently linked perylenediimide–diketopyrrolopyrrole–perylenediimide
acceptor–donor–acceptor molecule (PDI–DPP–PDI, 1) were investigated and found to …

Intended as an emergency response to the problem of “homelessness,” shelters have become
a common service, outliving the “temporary” label. Typically, the provision of refuge has …

… Hartnett-Scott for technical assistance. Funding: This work was supported by NSF grant
NSF-IOS-BSF 1655480 (to EA, TT, and MH) and NIH grants DC007905 (to TT), NS043277 (to EA…

Zinc, loaded into glutamate-containing presynaptic vesicles and released into the synapse
in an activity-dependent manner, modulates neurotransmission through its actions on …

Kv2.1 channels mediate cell death–enabling loss of cytosolic potassium in neurons following
plasma membrane insertion at somatodendritic clusters. Overexpression of the carboxyl …