The upcoming 5th edition of the World Health Organization (WHO) Classification of
Haematolymphoid Tumours is part of an effort to hierarchically catalogue human cancers arising in …

There is an increasing number of confirmed cases and deaths caused by the Severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) contributing to the Coronavirus disease …

CONTEXT: Pyruvate dehydrogenase complex (PDC) deficiency is a genetic mitochondrial
disorder commonly associated with lactic acidosis, progressive neurological and …

Exhausted CD8 + T (T ex ) cells in chronic infections and cancer have limited effector
function, high co-expression of inhibitory receptors and extensive transcriptional changes …

The BCL-2 inhibitor venetoclax combined with hypomethylating agents or low-dose
cytarabine represents an important new therapy for older or unfit patients with acute myeloid …

Azacitidine in combination with nivolumab appeared to be a safe and effective therapy in
patients with AML who were salvage 1, prior hypomethylator-naïve, or had increased …

Background Older patients with severe aortic stenosis (AS) are increasingly identified as
having cardiac amyloidosis (CA). It is unknown whether concomitant AS-CA has worse …

The pathophysiology of IDH mutations in tumorigenesis is increasingly described, yet the
prognostic significance of IDH1 and IDH2 mutations in AML remains controversial. The primary …

Transfer of next-generation sequencing technology to a Clinical Laboratory Improvement
Amendments–certified laboratory requires vigorous validation. Herein, we validated a next-…

Myeloid neoplasms and acute leukemias derive from the clonal expansion of hematopoietic
cells driven by somatic gene mutations. Although assessment of morphology plays a crucial …