Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

…, T Ooie, H Suzuki, N Shimada, K Chiba… - Pharmacology & …, 1997 - Elsevier
… Ideally, we can measure metabolic activity over a wide range of drug concentrations to
estimate K,,l and V,,,,i values. Then, the CL ,nt,,n UCTD can be calculated by Eq. (4). …

Expansive laminoplasty for myelopathy in ossification of the longitudinal ligament.

K Hirabayashi, Y Toyama, K Chiba - Clinical Orthopaedics and …, 1999 - journals.lww.com
… Tomimura et al 87 ; and between two segmental laminae using the Chiba University technique.
… Hirabayashi K, Satomi K: Expansive open-door laminoplasty for cervical spinal stenotic …

FTY720, a new class of immunomodulator, inhibits lymphocyte egress from secondary lymphoid tissues and thymus by agonistic activity at sphingosine 1-phosphate …

K Chiba - Pharmacology & therapeutics, 2005 - Elsevier
… (A) MHC-incompatible rat skin allograft was performed using WKAH rats (RT1 k ) as donors
and F344 rats (RT1 lv1 ) as recipients. (B) MHC-compatible rat skin allograft was performed …

[HTML][HTML] Landscape of genetic lesions in 944 patients with myelodysplastic syndromes

…, N Nadarajah, Y Shiraishi, Y Shiozawa, K Chiba… - Leukemia, 2014 - nature.com
High-throughput DNA sequencing significantly contributed to diagnosis and prognostication
in patients with myelodysplastic syndromes (MDS). We determined the biological and …

Integrated molecular analysis of clear-cell renal cell carcinoma

…, Y Nagata, K Yoshida, A Kon, Y Suzuki, K Chiba… - Nature …, 2013 - nature.com
Clear-cell renal cell carcinoma (ccRCC) is the most prevalent kidney cancer and its molecular
pathogenesis is incompletely understood. Here we report an integrated molecular study of …

Mutational landscape and clonal architecture in grade II and III gliomas

H Suzuki, K Aoki, K Chiba, Y Sato, Y Shiozawa… - Nature …, 2015 - nature.com
… of supporting reads was less than the minimum k value (k min ) that held the condition SE k
e −E /k! < 0.01 or the VAF was less than or equal to k min /mean depth. All variants that were …

Integrated molecular analysis of adult T cell leukemia/lymphoma

…, T Shimamura, J Yasunaga, Y Totoki, K Chiba… - Nature …, 2015 - nature.com
Adult T cell leukemia/lymphoma (ATL) is a peripheral T cell neoplasm of largely unknown
genetic basis, associated with human T cell leukemia virus type-1 (HTLV-1) infection. Here we …

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase

K Chiba, A Trevor, N Castagnoli Jr - Biochemical and biophysical research …, 1984 - Elsevier
The neurotoxic chemical MPTP (1-methyl-4-phenyl-1,2,4,5-tetrahydropyridine) is metabolized
by rat brain mitochrondrial fractions at a rate of 0.91 ± 0.02 nmoles/mg protein/min. The …

Somatic RHOA mutation in angioimmunoblastic T cell lymphoma

…, M Sanada, K Chiba, H Tanaka, K Suzukawa… - Nature …, 2014 - nature.com
Angioimmunoblastic T cell lymphoma (AITL) is a distinct subtype of peripheral T cell
lymphoma characterized by generalized lymphadenopathy and frequent autoimmune-like …

Aberrant PD-L1 expression through 3′-UTR disruption in multiple cancers

…, Y Nagata, A Kitanaka, S Mizuno, H Tanaka, K Chiba… - Nature, 2016 - nature.com
… This research also used computational resources of the K computer provided by the RIKEN
Advanced Institute for Computational Science through the HPCI System Research project (…