Clinical characteristics of clear cell carcinoma of the ovary: a distinct histologic type with poor prognosis and resistance to platinum‐based chemotherapy

T Sugiyama, T Kamura, J Kigawa… - … Journal of the …, 2000 - Wiley Online Library
BACKGROUND A retrospective review of treatment results comparing women with clear cell
carcinoma of the ovary (CCC) with a group with serous adenocarcinoma of the ovary (SAC) …

Expression of P-glycoprotein in human placenta: relation to genetic polymorphism of the multidrug resistance (MDR)-1 gene

…, Y Kanamori, M Takahashi, Y Kurata, J Kigawa… - … of Pharmacology and …, 2001 - ASPET
To evaluate whether mutations in the human multidrug resistance (MDR)-1 gene correlate
with placental P-glycoprotein (PGP) expression, we sequenced the MDR-1 cDNA and …

Functional assessment of ABCG2 (BCRP) gene polymorphisms to protein expression in human placenta

…, I Ieiri, T Hirota, H Takane, S Maegawa, J Kigawa… - Drug Metabolism and …, 2005 - ASPET
The aim of the present study was to assess the contribution of polymorphisms in the breast
cancer resistance protein/ATP-binding cassette transporter G2 (BCRP/ABCG2) gene to the …

Ovarian metastasis in carcinoma of the uterine cervix

M Shimada, J Kigawa, R Nishimura, S Yamaguchi… - Gynecologic …, 2006 - Elsevier
BACKGROUND.: The present study was conducted to determine the frequency and
clinicopathological features of ovarian metastasis in a large population of patients with stage Ib–IIb …

Mechanisms of chemoresistance and poor prognosis in ovarian clear cell carcinoma

H Itamochi, J Kigawa, N Terakawa - Cancer science, 2008 - Wiley Online Library
Clear cell carcinoma (CCC) accounts for 4% to 12% of epithelial ovarian cancer in Western
countries and, for some unknown reasons, it comprises more than 20% of such cancers in …

Detection of peritoneal dissemination in gynecological malignancy: evaluation by diffusion-weighted MR imaging

…, Y Kanamori, J Nakanishi, S Sugihara, J Kigawa… - European …, 2008 - Springer
The aim of this study is to evaluate the usefulness of diffusion-weighted (DW) magnetic
resonance (MR) imaging in detecting peritoneal dissemination in cases of gynecological …

Diagnostic accuracy of the apparent diffusion coefficient in differentiating benign from malignant uterine endometrial cavity lesions: initial results

S Fujii, E Matsusue, J Kigawa, S Sato, Y Kanasaki… - European …, 2008 - Springer
Our purpose is to evaluate the diagnostic accuracy of apparent diffusion coefficient (ADC)
measurement in differentiating malignant from benign uterine endometrial cavity lesions. We …

Diagnostic accuracy of diffusion‐weighted imaging in differentiating benign from malignant ovarian lesions

…, Y Kanasaki, T Harada, J Kigawa… - Journal of Magnetic …, 2008 - Wiley Online Library
Purpose To clarify the diagnostic accuracy of diffusion‐weighted imaging (DWI) in differentiating
benign from malignant ovarian lesions. Materials and Methods We retrospectively …

Correlation between loss of PTEN expression and Akt phosphorylation in endometrial carcinoma

Y Kanamori, J Kigawa, H Itamochi, M Shimada… - Clinical Cancer …, 2001 - AACR
The tumor suppressor PTEN acts as a lipid phosphatase, regulates the phosphatidylinositol
3-kinase (PI3K)/Akt-signaling pathway, and modulates cell cycle progression and cell …

Low proliferation activity may be associated with chemoresistance in clear cell carcinoma of the ovary

H Itamochi, J Kigawa, T Sugiyama… - Obstetrics & …, 2002 - journals.lww.com
OBJECTIVE To estimate whether and how the biologic behavior of clear cell carcinoma
contributes to the chemoresistance mechanism. METHODS Forty-one patients with clear cell …