[HTML][HTML] A comparative study on the hydroperoxide and thiol specificity of the glutathione peroxidase family and selenoprotein P
G Takebe, J Yarimizu, Y Saito, T Hayashi… - Journal of Biological …, 2002 - ASBMB
Glutathione peroxidase catalyzes the reduction of hydrogen peroxide and organic
hydroperoxide by glutathione and functions in the protection of cells against oxidative damage. …
hydroperoxide by glutathione and functions in the protection of cells against oxidative damage. …
Differential effects between γ-secretase inhibitors and modulators on cognitive function in amyloid precursor protein-transgenic and nontransgenic mice
Y Mitani, J Yarimizu, K Saita, H Uchino… - Journal of …, 2012 - Soc Neuroscience
γ-Secretase inhibitors (GSIs) reduce amyloid-β (Aβ) peptides but inevitably increase the β-C-terminal
fragment (β-CTF) of amyloid precursor protein (APP), potentially having …
fragment (β-CTF) of amyloid precursor protein (APP), potentially having …
Pharmacological characterization of a novel, potent adenosine A1 and A2A receptor dual antagonist, 5-[5-amino-3-(4-fluorophenyl) pyrazin-2-yl]-1-isopropylpyridine-2 …
T Mihara, K Mihara, J Yarimizu, Y Mitani… - … of Pharmacology and …, 2007 - ASPET
Central adenosine A 2A receptor is a promising target for drugs to treat Parkinson's disease
(PD), and the central blockade of adenosine A 1 receptor improves cognitive function. In the …
(PD), and the central blockade of adenosine A 1 receptor improves cognitive function. In the …
The evolutionarily conserved G protein-coupled receptor SREB2/GPR85 influences brain size, behavior, and vulnerability to schizophrenia
…, M Shobo, S Takahashi, J Yarimizu… - Proceedings of the …, 2008 - National Acad Sciences
The G protein-coupled receptor (GPCR) family is highly diversified and involved in many
forms of information processing. SREB2 (GPR85) is the most conserved GPCR throughout …
forms of information processing. SREB2 (GPR85) is the most conserved GPCR throughout …
Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine
A Nagakura, Y Shitaka, J Yarimizu… - European journal of …, 2013 - Elsevier
Alzheimer's disease is characterized by a progressive decline in cognitive function and involves
β-amyloid (Aβ) in its pathogenesis. To characterize cognitive deficits associated with Aβ …
β-amyloid (Aβ) in its pathogenesis. To characterize cognitive deficits associated with Aβ …
A novel glycine transporter-1 (GlyT1) inhibitor, ASP2535 (4-[3-isopropyl-5-(6-phenyl-3-pyridyl)-4H-1, 2, 4-triazol-4-yl]-2, 1, 3-benzoxadiazole), improves cognition in …
K Harada, K Nakato, J Yarimizu, M Yamazaki… - European journal of …, 2012 - Elsevier
Hypofunction of brain N-methyl-d-aspartate (NMDA) receptors has been implicated in
psychiatric disorders such as schizophrenia and Alzheimer's disease. Inhibition of glycine …
psychiatric disorders such as schizophrenia and Alzheimer's disease. Inhibition of glycine …
[HTML][HTML] ASP5736, a novel 5-HT5A receptor antagonist, ameliorates positive symptoms and cognitive impairment in animal models of schizophrenia
…, K Harada, N Yamamoto, J Yarimizu… - European …, 2014 - Elsevier
We recently identified ASP5736, (N-(diaminomethylene)-1-(3,5-difluoropyridin-4-yl)-4-fluoroisoquinoline-7-carboxamide
(2E)-but-2-enedioate), a novel antagonist of 5-HT 5A receptor, …
(2E)-but-2-enedioate), a novel antagonist of 5-HT 5A receptor, …
[HTML][HTML] Novel 5-HT5A receptor antagonists ameliorate scopolamine-induced working memory deficit in mice and reference memory impairment in aged rats
M Yamazaki, M Okabe, N Yamamoto, J Yarimizu… - Journal of …, 2015 - Elsevier
Despite the human 5-HT 5A receptor being cloned in 1994, the biological function of this
receptor has not been extensively characterized due to a lack of specific ligands. We recently …
receptor has not been extensively characterized due to a lack of specific ligands. We recently …
5-HT5A Receptor Antagonist ASP5736 Ameliorates Several Abnormal Behaviors in an Fmr1-Targeted Transgenic Male Rat Model of Fragile X Syndrome
M Yamazaki, T Arai, J Yarimizu… - International Journal of …, 2022 - academic.oup.com
… Acquisition, analysis, or interpretation of data: Yamazaki, Arai, and Yarimizu. Drafting … ,
Yarimizu, and Matsumoto. Final approval of the version to be published: Yamazaki, Arai, Yarimizu, …
Yarimizu, and Matsumoto. Final approval of the version to be published: Yamazaki, Arai, Yarimizu, …
Optimization and biological evaluation of imidazopyridine derivatives as a novel scaffold for γ-secretase modulators with oral efficacy against cognitive deficits in …
R Sekioka, S Honda, H Akashiba, J Yarimizu… - Bioorganic & Medicinal …, 2020 - Elsevier
Gamma-secretase modulators (GSMs) selectively lower amyloid-β42 (Aβ42) and are
therefore potential disease-modifying drugs for Alzheimer’s disease (AD). Here, we report the …
therefore potential disease-modifying drugs for Alzheimer’s disease (AD). Here, we report the …