Here, we describe the preclinical pharmacological profile of 5-[(R)-2-(5,6-diethyl-indan-2-ylamino)-1-hydroxy-ethyl]-8-hydroxy-1H-quinolin-2-one
(indacaterol), a novel, chirally pure …

The advent of miniaturized assay formats has made possible the screening of large numbers
of compounds against a single target, known as high-throughput screening. Despite this …

The mechanism by which ATP primes for subsequent macrophage-derived chemokine (MDC)
mediated intracellular calcium (Ca 2+ i ) responses at the human CCR4 receptor stably …

The Wnt/β-catenin signaling pathbway controls many important biological processes. R-Spondin
(RSPO) proteins are a family of secreted molecules that strongly potentiate Wnt/β-…

Studies under nonphysiological conditions suggest that long receptor residency time is
responsible for the 24-h duration of action of the long-acting muscarinic antagonist (LAMA) …

Host factor pathways are known to be essential for hepatitis C virus (HCV) infection and
replication in human liver cells. To search for novel host factor proteins required for HCV …

TLQP-21, a peptide derived from VGF (non-acronymic) by proteolytic processing, has been
shown to modulate energy metabolism, differentiation, and cellular response to stress. …

Metallothioneins are proteins that are involved in intracellular zinc storage and transport.
Their expression levels have been reported to be elevated in several settings of skeletal …

Background Hearing loss is the most common sensory defect afflicting several hundred million
people worldwide. In most cases, regardless of the original cause, hearing loss is related …

A library of chemokine antagonists has been synthesized using a combination of solid and
solution-phase chemistry. Structures of known chemokine antagonists were used to produce …