[HTML][HTML] The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids
…, KM Steplewski, PR Murdock, JC Holder… - Journal of Biological …, 2003 - ASBMB
GPR41 and GPR43 are related members of a homologous family of orphan G protein-coupled
receptors that are tandemly encoded at a single chromosomal locus in both humans and …
receptors that are tandemly encoded at a single chromosomal locus in both humans and …
[PDF][PDF] Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription
…, DG Smith, KJ Murray, AD Reith, JC Holder - Chemistry & biology, 2000 - cell.com
Background: Glycogen synthase kinase-3 (GSK-3) is a serine/threonine protein kinase, the
activity of which is inhibited by a variety of extracellular stimuli including insulin, growth factors…
activity of which is inhibited by a variety of extracellular stimuli including insulin, growth factors…
Activators of peroxisome proliferator-activated receptor gamma have depot-specific effects on human preadipocyte differentiation.
…, CT Montague, JB Prins, JC Holder… - The Journal of …, 1997 - Am Soc Clin Investig
Activation of peroxisome proliferator-activated receptor (PPAR) gamma, a nuclear receptor
highly expressed in adipocytes, induces the differentiation of murine preadipocyte cell lines. …
highly expressed in adipocytes, induces the differentiation of murine preadipocyte cell lines. …
PPAR-γ agonists: therapeutic role in diabetes, inflammation and cancer
GJ Murphy, JC Holder - Trends in pharmacological sciences, 2000 - cell.com
The recent development of a novel class of insulin-sensitizing drugs, the thiazolidinediones (TZDs),
represents a significant advance in antidiabetic therapy. One key mechanism by …
represents a significant advance in antidiabetic therapy. One key mechanism by …
[HTML][HTML] Peroxisome proliferator-activated receptor (PPAR)-β/δ stimulates differentiation and lipid accumulation in keratinocytes
M Schmuth, CM Haqq, WJ Cairns, JC Holder… - Journal of Investigative …, 2004 - Elsevier
Peroxisome proliferator-activated receptor (PPAR) are nuclear hormone receptors that are
activated by endogenous lipid metabolites. Previous studies have demonstrated that PPAR-α …
activated by endogenous lipid metabolites. Previous studies have demonstrated that PPAR-α …
Identification of high-affinity binding sites for the insulin sensitizer rosiglitazone (BRL-49653) in rodent and human adipocytes using a radioiodinated ligand for …
…, PJ Coyle, D Haigh, RM Hindley, JC Holder… - … of Pharmacology and …, 1998 - ASPET
A radioiodinated ligand, [ 125 I]SB-236636 [(S)-(−)3-[4-[2-[N-(2-benzoxazolyl)-N-methylamino]ethoxy]3-[
125 I]iodophenyl]2-ethoxy propanoic acid], which is specific for the γ isoform of …
125 I]iodophenyl]2-ethoxy propanoic acid], which is specific for the γ isoform of …
[HTML][HTML] Insulin activates protein kinase B, inhibits glycogen synthase kinase-3 and activates glycogen synthase by rapamycin-insensitive pathways in skeletal muscle …
…, M Shaw, J Van Der Kaay, CP Downes, JC Holder… - FEBS letters, 1997 - Elsevier
Insulin stimulated protein kinase Bα (PKBα) more than 10-fold and decreased glycogen
synthase kinase-3 (GSK3) activity by 50±10% in skeletal muscle and adipocytes. Rapamycin did …
synthase kinase-3 (GSK3) activity by 50±10% in skeletal muscle and adipocytes. Rapamycin did …
Insulin and rosiglitazone regulation of lipolysis and lipogenesis in human adipose tissue in vitro
…, LA Anderson, A Green, SA Smith, JC Holder… - Diabetes, 2002 - Am Diabetes Assoc
Lipolysis is an important process determining fuel metabolism, and insulin regulates this
process in adipose tissue. The aim of this study was to investigate the long-term effects of insulin…
process in adipose tissue. The aim of this study was to investigate the long-term effects of insulin…
Astrocyte-derived pentraxin 3 supports blood–brain barrier integrity under acute phase of stroke
…, N Egawa, K Itoh, N Itoh, M Borlongan, JC Holder… - Stroke, 2016 - Am Heart Assoc
Background and Purpose— Pentraxin 3 (PTX3) is released on inflammatory responses in
many organs. However, roles of PTX3 in brain are still mostly unknown. Here we asked …
many organs. However, roles of PTX3 in brain are still mostly unknown. Here we asked …
Differential regulation of adipocytokine mRNAs by rosiglitazone in db/db mice
GBT Moore, H Chapman, JC Holder, CA Lister… - Biochemical and …, 2001 - Elsevier
The precise mechanism by which PPARγ activation by thiazolidinediones (TZDs) improves
insulin sensitivity is still unclear. Recent studies have focused on the role of adipocytokines in …
insulin sensitivity is still unclear. Recent studies have focused on the role of adipocytokines in …