Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide 1 , 2
. Although 58 genomic regions have been associated with CAD thus far 3 , 4 , 5 , 6 , 7 , 8 , 9 , …

Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown.
We conducted a multiancestry genome-wide-association meta-analysis in 521,612 …

Warfarin is a widely used anticoagulant with a narrow therapeutic index and large interpatient
variability in the dose required to achieve target anticoagulation. Common genetic variants …

CYP2C19 catalyzes the bioactivation of the antiplatelet prodrug clopidogrel, and CYP2C19
genotype impacts clopidogrel active metabolite formation. CYP2C19 intermediate and poor …

Warfarin is an effective, commonly prescribed anticoagulant used to treat and prevent thrombotic
events. Because of historically high rates of drug-associated adverse events, warfarin …

This document is an update to the 2011 Clinical Pharmacogenetics Implementation Consortium
(CPIC) guideline for CYP2C9 and VKORC1 genotypes and warfarin dosing. Evidence …

Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate
genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), …

It is well recognized that most medications exhibit wide interpatient variability in their efficacy
and toxicity. For many medications, these interindividual differences are due in part to …

(Supplementary Tables 1b–e online) also revealed a higher expression in hES cells with an
abnormal karyotype (late CT) compared with the other three karyotypically normal groups. …

To identify genetic factors contributing to type 2 diabetes (T2D), we performed large-scale
meta-analyses by using a custom ∼50,000 SNP genotyping array (the ITMAT-Broad-CARe …