Acetaminophen (APAP), a widely used over-the-counter analgesic, is known to cause
hepatotoxicity when ingested in large quantities in both animals and man, especially when …

The peroxisome proliferator activated receptor α (PPAR) is a member of the steroid/hormone
receptor superfamily that mediates the peroxisome proliferator-dependent transcriptional …

The human P450111 family has been shown to be composed of at least four members,
P450I1IA3 (HLp), P450II1A4(P45ONF), P45OlIlA5(HLp3), and P450I1IA6(HLp2). Due to the lack …

Numerous halogenated hydrocarbons of the alkane, alkene, and alkyne classes are
metabolized by P450 enzymes to products that elicit cytotoxic and/or carcinogenic effects. Such …

Human CYP3A4 metabolizes a majority of clinically important substrates at variable rates.
Accounting for these unpredictable rates is the wide variation noted in expression of this …

Revised Manuscript Received December 27, 1990 abstract: The present study characterizes
the profile of cDNAs from the human P450IIC subfamily in a library from one individual, and …

In the present study, the regio- and stereoselective epoxidation of arachidonic acid by
cytochromes P450 2C8 and 2C9, two members of the CYP2C gene subfamily expressed in …

Hepatic microsomal metabolism of delta 1-tetrahydrocannabinol (THC) has been
extensively studied in many rodent species, but there have been few reports describing such …

Although CYP2C8, CYP2C9, and CYP2C19 play an important role in drug biotransformation,
factors influencing the expression and activity of these CYP2C P450s in human liver …

Cytochrome P45011E1 (IIE1) is a microsomal xenobiotic-activating enzyme that is inducible
not only by various chemical agents but also by fasting and diabetes. Using a rat model that …