Some patients with acute hereditary porphyrias have seizures and require anticonvulsant
therapy, but many anticonvulsants induce exacerbations of the hepatic porphyrias. Recently, …

Heme oxygenase catalyzes the degradation of heme into biliverdin, carbon monoxide, and
iron. Two forms of this enzyme, heme oxygenase-1 and -2, have been identified; only heme …

When patients with acute porphyrias are treated with antihypertensives and analgesics, they
could be placed at increased risk of developing porphyric attacks, since little is known about …

Mifepristone (RU‐486), a potent progesterone receptor antagonist and inducer of cytochromes
P ‐450, is currently in use in Europe, particularly as a post‐coital oral contraceptive. Soon …

Induction of heme oxygenase (HO) has been proposed as a protective cellular mechanism
against oxidative damage. In previous work (Tyrrell et al., Carcinogenesis [1993] 14, 761–765…

Patients with any of the acute porphyrias may suffer from acute attacks. If these patients are
treated with certain drugs, such as barbiturates, the likelihood of developing an attack is …

The acute porphyrias in relapse are commonly treated with intravenous heme infusion to
decrease the activity of delta-aminolevulinic acid synthase, normally the rate-controlling …

Hepatic 5‐aminolevulinic acid synthase, the first and normally rate‐controlling enzyme of
heme biosynthesis, is regulated by heme. One of the known mechanisms whereby increased …

We characterize a liver cell culture model for acute hepatic porphyrias that recapitulates the
biochemical features of the human syndrome. In chick embryo liver cells in primary culture …

Heme oxygenase catalyzes the first and rate-controlling step in heme catabolism. One of
the two forms of heme oxygenase (heme oxygenase-1) has been shown to be increased by …