Discovery of histamine H3 antagonists for the treatment of cognitive disorders and Alzheimer's disease

JD Brioni, TA Esbenshade, TR Garrison… - … of Pharmacology and …, 2011 - ASPET
H 3 antagonists increase the release of brain histamine, acetylcholine, noradrenaline, and
dopamine, neurotransmitters that are known to modulate cognitive processes. The ability to …

Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test

JD Brioni, AB O'Neill, DJB Kim, MW Decker - European journal of …, 1993 - Elsevier
The effects of nicotinic receptor agonists on the elevated plus-maze test of anxiety were
investigated in CD1 mice after intraperitoneal injections. Nicotine and lobeline, but not cytisine, …

Localization of histamine H4 receptors in the central nervous system of human and rat

…, AM Manelli, GC Hsieh, TA Esbenshade, JD Brioni… - Brain research, 2009 - Elsevier
Existing data on the expression of H 4 histamine receptor in the CNS are conflicting and
inconclusive. In this report, we present the results of experiments that were conducted in order to …

Diversity of neuronal nicotinic acetylcholine receptors: lessons from behavior and implications for CNS therapeutics

MW Decker, JD Brioni, AW Bannon, SP Arneric - Life sciences, 1995 - Elsevier
Although the molecular biology of neuronal nicotinic acetylcholine receptors (nAChRs)
provides evidence for multiple receptor subtypes, few selective pharmacological tools exist to …

Functional characterization of the novel neuronal nicotinic acetylcholine receptor ligand GTS-21 in vitro and in vivo

CA Briggs, DJ Anderson, JD Brioni… - Pharmacology …, 1997 - Elsevier
[2, 4]-Dimethoxybenzylidene anabaseine dihydrochloride (GTS-21), a compound that interacts
with rat neuronal nicotinic acetylcholine receptors (nAChRs), was evaluated using human …

Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels

…, P Honoré, AO Stewart, RB Moreland, JD Brioni - Pain, 2005 - Elsevier
Acid Sensing Ion Channels (ASICs) are a group of sodium-selective ion channels that are
activated by low extracellular pH. The role of ASIC in disease states remains unclear partly …

[HTML][HTML] A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics

JD Brioni, S Varughese, R Ahmed, B Bein - Journal of anesthesia, 2017 - Springer
A large number of studies during the past two decades have demonstrated the efficacy and
safety of sevoflurane across patient populations. Clinical researchers have also investigated …

Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors

…, OF El Kouhen, SW Muchmore, JD Brioni… - Journal of medicinal …, 2009 - ACS Publications
High-throughput screening (HTS) identified benzothiazole analogue 3 as a potent fatty acid
amide hydrolase (FAAH) inhibitor. Structure−activity relationship (SAR) studies indicated that …

Involvement of the amygdala GABAergic system in the modulation of memory storage

JD Brioni, AH Nagahara, JL McGaugh - Brain research, 1989 - Elsevier
These experiments examined the involvement of the intrinsic GABAergic system of the
amygdaloid complex in the modulation of memory storage. Rats were chronically implanted with …

Influence of separate and combined septal and amygdala lesions on memory, acoustic startle, anxiety, and locomotor activity in rats

MW Decker, P Curzon, JD Brioni - Neurobiology of learning and memory, 1995 - Elsevier
The septohippocampal system and the amygdala have been implicated in cognitive and
emotional processes. A series of experiments was conducted to examine the effects of separate …