[HTML][HTML] Targeting mast cells in allergic disease: current therapies and drug repurposing
JR Burchett, JM Dailey, SA Kee, DT Pryor, A Kotha… - Cells, 2022 - mdpi.com
The incidence of allergic disease has grown tremendously in the past three generations.
While current treatments are effective for some, there is considerable unmet need. Mast cells …
While current treatments are effective for some, there is considerable unmet need. Mast cells …
Fluoxetine restrains allergic inflammation by targeting an FcɛRI-ATP positive feedback loop in mast cells
TT Haque, MT Taruselli, SA Kee, JM Dailey… - Science …, 2023 - science.org
There is a clinical need for new treatment options addressing allergic disease. Selective
serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that have anti-inflammatory …
serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that have anti-inflammatory …
IL-33 priming amplifies ATP-mediated mast cell cytokine production
DB Straus, D Pryor, TT Haque, SA Kee, JM Dailey… - Cellular …, 2022 - Elsevier
Inflammatory responses are required to block pathogen infection but can also lead to
hypersensitivity and chronic inflammation. Barrier tissues actively release IL-33, ATP, and other …
hypersensitivity and chronic inflammation. Barrier tissues actively release IL-33, ATP, and other …
Inhibiting Isoprenylation Suppresses FcεRI-Mediated Mast Cell Function and Allergic Inflammation
JM Dailey, SA Kee, A Tharakan, A Kazi… - The Journal of …, 2023 - journals.aai.org
IgE-mediated mast cell activation is a driving force in allergic disease in need of novel
interventions. Statins, long used to lower serum cholesterol, have been shown in multiple large-…
interventions. Statins, long used to lower serum cholesterol, have been shown in multiple large-…
Fluvastatin induces apoptosis in primary and transformed mast cells
…, M Kolawole, MT Taruselli, S Ajith, JM Dailey… - … of Pharmacology and …, 2020 - ASPET
Statin drugs are widely employed in the clinic to reduce serum cholesterol. Because of their
hydroxymethylglutaryl coenzyme A reductase antagonism, statins also reduce isoprenyl …
hydroxymethylglutaryl coenzyme A reductase antagonism, statins also reduce isoprenyl …
IL-33 Induces Cellular and Exosomal miR-146a Expression as a Feedback Inhibitor of Mast Cell Function
…, D Abebayehu, HL Caslin, JM Dailey… - The Journal of …, 2024 - journals.aai.org
IL-33 is an inflammatory cytokine that promotes allergic disease by activating group 2 innate
lymphoid cells, Th2 cells, and mast cells. IL-33 is increased in asthmatics, and its blockade …
lymphoid cells, Th2 cells, and mast cells. IL-33 is increased in asthmatics, and its blockade …
Fluvastatin enhances IL-33-mediated mast cell IL-6 and TNF production
…, HL Caslin, D Abebayehu, SA Kee, JM Dailey… - Cellular …, 2022 - Elsevier
Statins are HMG-CoA reductase inhibitors prescribed for lowering cholesterol. They can
also inhibit inflammatory responses by suppressing isoprenylation of small G proteins. …
also inhibit inflammatory responses by suppressing isoprenylation of small G proteins. …
Isoprenylation Inhibition Suppresses FcεRI-mediated Mast Cell Function and Allergic Inflammation
Allergic disease is driven by cell signaling cascades that activate immune cells. One key
player is mast cells, which is activated by IgE antibodies signaling through the high affinity IgE …
player is mast cells, which is activated by IgE antibodies signaling through the high affinity IgE …
The HMGCR Inhibitor Fluvastatin Induces Apoptosis and Autophagy in Primary and Neoplastic Mast Cells
BO Barnstein, PA Paez, JM Dailey… - The Journal of …, 2019 - journals.aai.org
Mast cell hyperplasia is noted in many inflammatory and allergic diseases. Mast cells can
also generate a subtype of acute myelogenous leukemia. Understanding and treating mast …
also generate a subtype of acute myelogenous leukemia. Understanding and treating mast …
Organization of face and object recognition in modular neural network models
MN Dailey, GW Cottrell - Neural networks, 1999 - Elsevier
There is strong evidence that face processing in the brain is localized. The double dissociation
between prosopagnosia, a face recognition deficit occurring after brain damage, and …
between prosopagnosia, a face recognition deficit occurring after brain damage, and …