Cells maintain intracellular pH (pH i ) within a narrow range (7.1–7.2) by controlling membrane
proton pumps and transporters whose activity is set by intra-cytoplasmic pH sensors. …

Despite advances in developing novel therapeutic strategies, a major factor underlying
cancer related death remains resistance to therapy. In addition to biochemical resistance, …

Cancer immunotherapies, such as immune checkpoint blockade or adoptive T-cell transfer,
can lead to durable responses in the clinic, but response rates remain low due to undefined …

Metastasis is a multistep process that culminates in the spread of cells from a primary tumor
to a distant site or organs. For tumor cells to be able to metastasize, they have to locally …

Tumor cell survival relies upon adaptation to the acidic conditions of the tumor microenvironment.
To investigate potential acidosis survival mechanisms, we examined the effect of low …

Early cancers are avascular and hence, profoundly acidic. Pre-malignant cells must adapt to
acidosis to thrive in this hostile microenvironment. Here, we investigate MCF-7 cells that are …

The observation of aerobic glycolysis by tumor cells in 1924 by Otto Warburg, and subsequent
innovation of imaging glucose uptake by tumors in patients with PET-CT, has incited a …

The dynamic cancer ecosystem, with its rich temporal and spatial diversity in environmental
conditions and heritable cell phenotypes, is remarkably robust to therapeutic perturbations. …

Ongoing intratumoral evolution is apparent in molecular variations among cancer cells from
different regions of the same tumor, but genetic data alone provide little insight into …

Genomic instability and high mutation rates cause cancer to acquire numerous mutations
and chromosomal alterations during its somatic evolution; most are termed passengers …