Obesity-related leptin resistance manifests in loss of leptin's ability to reduce appetite and
increase energy expenditure. Obesity is also associated with increased activity of the …

This experiment examined both the short-term and the long-term effects of ovariectomy on
brown adipose tissue growth and function in rats to determine if reduced brown adipose tissue …

Analogs of SLV-319 (Ibipinibant), a CB1 receptor inverse agonist, were synthesized with
functionality intended to limit brain exposure while maintaining the receptor affinity and …

Structure−activity studies in the pyrazolo[1,5-a]-1,3,5-triazine series led to the discovery that
compound 11i (DMP696) is a potent hCRF 1 receptor antagonist (K i = 1.7 nM vs 7.5 nM for α…

The fifth part of a century almost has sped with the flight of time since the outbreak of the
Slaveholders' Rebellion against the United States. The young men of to-day were then babes in …

Structure–activity relationship studies led to the discovery of 4-(3-pentylamino)-2,7-dimethyl-8-(2-methyl-4-methoxyphenyl)-pyrazolo-[1,5-a]-pyrimidine
11-31 (DMP904), whose …

receptor ligands represent a new class of potential antipsychotic drugs. This paper presents
the structure-activity relationships leading to novel disubstituted piperidine ligands, which …

This experiment examined the effect of short photoperiod on food intake, body weight,
carcass composition, and brown adipose tissue (BAT) activity in female Syrian hamsters (…

The discovery of N-substituted-pyridoindolines and their binding affinities at the 5-HT 2A , 5-HT
2C and D 2 receptors, and in vivo efficacy as 5-HT 2A antagonists is described. The …

This report describes the syntheses and structure−activity relationships of 8-(substituted
pyridyl)pyrazolo[1,5-a]-1,3,5-triazine corticotropin releasing factor receptor-1 (CRF 1 ) receptor …