Nonpeptidic δ-opioid receptor agonists reduce immobility in the forced swim assay in rats

DC Broom, EM Jutkiewicz, JE Folk, JR Traynor… - …, 2002 - Elsevier
The present study examined the effect of opioid receptor agonists in the rat forced swim
assay. The δ-opioid receptor agonists SNC80 ((+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-…

[HTML][HTML] Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats

EC Stoffel, CM Ulibarri, JE Folk, KC Rice, RM Craft - The Journal of Pain, 2005 - Elsevier
Previous studies suggest that sex differences in morphine antinociception in rodents might
be attributed to the activational effects of gonadal hormones. The present study determined …

Convulsant activity of a non-peptidic δ-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats

DC Broom, EM Jutkiewicz, JE Folk, JR Traynor… - …, 2002 - Springer
Rationale. Non-peptidic δ-opioid receptor agonists possess antidepressant-like activity in
the forced swim assay in the rat. These compounds have also previously been shown to …

The convulsive and electroencephalographic changes produced by nonpeptidic δ-opioid agonists in rats: comparison with pentylenetetrazol

EM Jutkiewicz, MG Baladi, JE Folk, KC Rice… - … of Pharmacology and …, 2006 - ASPET
δ-Opioid agonists produce convulsions and antidepressant-like effects in rats. It has been
suggested that the antidepressant-like effects are produced through a convulsant mechanism …

Synthesis and pharmacological evaluation of 3-(3, 4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters

H Yu, IJ Kim, JE Folk, X Tian, RB Rothman… - Journal of medicinal …, 2004 - ACS Publications
In our efforts toward developing a nonselective ligand that would block the effects of stimulants
such as methamphetamine at dopamine (DA), serotonin (5-HT), and norepinephrine (NE) …

[HTML][HTML] The δ-opioid receptor agonist (+) BW373U86 regulates BDNF mRNA expression in rats

MM Torregrossa, C Isgor, JE Folk, KC Rice… - …, 2004 - nature.com
δ-Opioid receptor agonists have antidepressant-like effects in behavioral models of depression.
Chronic administration of classical antidepressants upregulates mRNA expression of …

Increased levels of γ‐glutamylamines in Huntington disease CSF

TM Jeitner, WR Matson, JE Folk… - Journal of …, 2008 - Wiley Online Library
Transglutaminases (TGases) catalyze several reactions with protein substrates, including
formation of γ‐glutamyl‐ε‐lysine cross‐links and γ‐glutamylpolyamine residues. The resulting γ…

The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats

GP Do Carmo, JE Folk, KC Rice, E Chartoff… - European journal of …, 2009 - Elsevier
Delta opioid receptor agonists are under development for a variety of clinical applications,
and some findings in rats raise the possibility that agents with this mechanism have abuse …

Interactions between δ and μ opioid agonists in assays of schedule-controlled responding, thermal nociception, drug self-administration, and drug versus food choice …

GW Stevenson, JE Folk, KC Rice, SS Negus - Journal of Pharmacology and …, 2005 - ASPET
Interactions between δ and μ opioid agonists in rhesus monkeys vary as a function of the
behavioral endpoint. The present study compared interactions between the δ agonist SNC80 [(…

δ-Opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats

EM Jutkiewicz, EB Eller, JE Folk, KC Rice… - … of Pharmacology and …, 2004 - ASPET
The diarylpiperazine δ-opioid agonist SNC80 [(+)-4-[(αR)-α-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide]
produces convulsions…