Nonpeptidic δ-opioid receptor agonists reduce immobility in the forced swim assay in rats
DC Broom, EM Jutkiewicz, JE Folk, JR Traynor… - …, 2002 - Elsevier
The present study examined the effect of opioid receptor agonists in the rat forced swim
assay. The δ-opioid receptor agonists SNC80 ((+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-…
assay. The δ-opioid receptor agonists SNC80 ((+)-4-[(αR)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-…
[HTML][HTML] Gonadal hormone modulation of mu, kappa, and delta opioid antinociception in male and female rats
EC Stoffel, CM Ulibarri, JE Folk, KC Rice, RM Craft - The Journal of Pain, 2005 - Elsevier
Previous studies suggest that sex differences in morphine antinociception in rodents might
be attributed to the activational effects of gonadal hormones. The present study determined …
be attributed to the activational effects of gonadal hormones. The present study determined …
Convulsant activity of a non-peptidic δ-opioid receptor agonist is not required for its antidepressant-like effects in Sprague-Dawley rats
DC Broom, EM Jutkiewicz, JE Folk, JR Traynor… - …, 2002 - Springer
Rationale. Non-peptidic δ-opioid receptor agonists possess antidepressant-like activity in
the forced swim assay in the rat. These compounds have also previously been shown to …
the forced swim assay in the rat. These compounds have also previously been shown to …
The convulsive and electroencephalographic changes produced by nonpeptidic δ-opioid agonists in rats: comparison with pentylenetetrazol
EM Jutkiewicz, MG Baladi, JE Folk, KC Rice… - … of Pharmacology and …, 2006 - ASPET
δ-Opioid agonists produce convulsions and antidepressant-like effects in rats. It has been
suggested that the antidepressant-like effects are produced through a convulsant mechanism …
suggested that the antidepressant-like effects are produced through a convulsant mechanism …
Synthesis and pharmacological evaluation of 3-(3, 4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters
H Yu, IJ Kim, JE Folk, X Tian, RB Rothman… - Journal of medicinal …, 2004 - ACS Publications
In our efforts toward developing a nonselective ligand that would block the effects of stimulants
such as methamphetamine at dopamine (DA), serotonin (5-HT), and norepinephrine (NE) …
such as methamphetamine at dopamine (DA), serotonin (5-HT), and norepinephrine (NE) …
[HTML][HTML] The δ-opioid receptor agonist (+) BW373U86 regulates BDNF mRNA expression in rats
MM Torregrossa, C Isgor, JE Folk, KC Rice… - …, 2004 - nature.com
δ-Opioid receptor agonists have antidepressant-like effects in behavioral models of depression.
Chronic administration of classical antidepressants upregulates mRNA expression of …
Chronic administration of classical antidepressants upregulates mRNA expression of …
Increased levels of γ‐glutamylamines in Huntington disease CSF
TM Jeitner, WR Matson, JE Folk… - Journal of …, 2008 - Wiley Online Library
Transglutaminases (TGases) catalyze several reactions with protein substrates, including
formation of γ‐glutamyl‐ε‐lysine cross‐links and γ‐glutamylpolyamine residues. The resulting γ…
formation of γ‐glutamyl‐ε‐lysine cross‐links and γ‐glutamylpolyamine residues. The resulting γ…
The selective non-peptidic delta opioid agonist SNC80 does not facilitate intracranial self-stimulation in rats
GP Do Carmo, JE Folk, KC Rice, E Chartoff… - European journal of …, 2009 - Elsevier
Delta opioid receptor agonists are under development for a variety of clinical applications,
and some findings in rats raise the possibility that agents with this mechanism have abuse …
and some findings in rats raise the possibility that agents with this mechanism have abuse …
Interactions between δ and μ opioid agonists in assays of schedule-controlled responding, thermal nociception, drug self-administration, and drug versus food choice …
GW Stevenson, JE Folk, KC Rice, SS Negus - Journal of Pharmacology and …, 2005 - ASPET
Interactions between δ and μ opioid agonists in rhesus monkeys vary as a function of the
behavioral endpoint. The present study compared interactions between the δ agonist SNC80 [(…
behavioral endpoint. The present study compared interactions between the δ agonist SNC80 [(…
δ-Opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats
EM Jutkiewicz, EB Eller, JE Folk, KC Rice… - … of Pharmacology and …, 2004 - ASPET
The diarylpiperazine δ-opioid agonist SNC80 [(+)-4-[(αR)-α-[(2S,5R)-2,5-dimethyl-4-(2-propenyl)-1-piperazinyl]-(3-methoxyphenyl)methyl]-N,N-diethylbenzamide]
produces convulsions…
produces convulsions…