The liver is the major source of reduced glutathione (GSH) in blood plasma. The transport
protein mediating the efflux of GSH across the basolateral membrane of human hepatocytes …

Bilirubin is secreted from the liver into bile mainly as monoglucuronosyl and bisglucuronosyl
conjugates. We demonstrate for the first time that ATP-dependent transport of both bilirubin …

The secretion of bilirubin conjugates from hepatocytes into bile represents a decisive step in
the prevention of hyperbilirubinemia. The bilirubin conjugates, monoglucuronosyl bilirubin (…

The multidrug resistance protein ABCC4 (MRP4), a member of the ATP-binding cassette
superfamily, mediates ATP-dependent unidirectional efflux of organic anions out of cells. …

The proinflammatory mediators leukotriene (LT) B 4 and LTC 4 must be transported out of
cells before they can interact with LT receptors. Previously, we identified the multidrug …

ATP-dependent para-aminohippurate transport by the apical multidrug resistance protein
MRP2. Background Para-aminohippurate (PAH), a widely used model substrate for organic …

Absence of a functional multidrug resistance protein 2 (MRP2; symbol ABCC2) from the
hepatocyte canalicular membrane is the molecular basis of Dubin- Johnson syndrome, an …

The nucleoside analog 5-azacytidine is an archetypical drug for epigenetic cancer therapy,
and its clinical effectiveness has been demonstrated in the treatment of myelodysplastic …

CCK-8 (l-aspartyl-l-tyrosyl-l-methionylglycyl-l-tryptophyl-l-methionyl-l-aspartyl-l-phenylalaninamide
hydrogen sulfate ester), a derivative of the gastrointestinal peptide hormone …

Despite a strong rationale for why cancer cells are susceptible to redox-targeting drugs, such
drugs often face tumor resistance or dose-limiting toxicity in preclinical and clinical studies. …